INT299668

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SCIN) cytoplasm (SCIN)
Anatomy Link Frequency
cleavage 3
SCIN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 4 35.20 Quite Low
Inflammation 26 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
spastic colon 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 46 82.00 Quite High
Appetite Loss 3 67.44 Quite High
Diarrhoea 41 59.60 Quite High
Adhesions 4 51.68 Quite High
Cellulitis 3 36.40 Quite Low
INFLAMMATION 35 35.20 Quite Low
Infection 39 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Hemolysis 9 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
sciN is a critical gene necessary for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation [80].
Localization (secretion) of sciN
1) Confidence 0.25 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.43 Pain Relevance 0
Another mechanism to prevent recognition is by inactivating IgG, either directly by proteases IdeS, Mac-2, and SpeB, or indirectly by SAK-activated plasmin. b There are three ways by which S. aureus and GAS modulate opsonization: (1) C3 cleavage; directly by SpeB or indirectly by SAK-mediated activated plasmin ClfA binds human fI, thereby enhancing C3 cleavage. (2) Convertase modulation; S. aureus inactivates the C3 convertases by secreting SCIN, SCIN-B, SCIN-C, Efb, and Ecb. (3) Modulating host regulators; Sbi and the streptococcal M-protein bind the negative convertase regulators (human FH, FHL1, C4BP, and CD46) while SpeB cleaves the positive convertase regulator, properdin
Localization (secreting) of SCIN-B in cleavage
2) Confidence 0.13 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0 Pain Relevance 0
Another mechanism to prevent recognition is by inactivating IgG, either directly by proteases IdeS, Mac-2, and SpeB, or indirectly by SAK-activated plasmin. b There are three ways by which S. aureus and GAS modulate opsonization: (1) C3 cleavage; directly by SpeB or indirectly by SAK-mediated activated plasmin ClfA binds human fI, thereby enhancing C3 cleavage. (2) Convertase modulation; S. aureus inactivates the C3 convertases by secreting SCIN, SCIN-B, SCIN-C, Efb, and Ecb. (3) Modulating host regulators; Sbi and the streptococcal M-protein bind the negative convertase regulators (human FH, FHL1, C4BP, and CD46) while SpeB cleaves the positive convertase regulator, properdin
Localization (secreting) of SCIN in cleavage
3) Confidence 0.13 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0 Pain Relevance 0
Another mechanism to prevent recognition is by inactivating IgG, either directly by proteases IdeS, Mac-2, and SpeB, or indirectly by SAK-activated plasmin. b There are three ways by which S. aureus and GAS modulate opsonization: (1) C3 cleavage; directly by SpeB or indirectly by SAK-mediated activated plasmin ClfA binds human fI, thereby enhancing C3 cleavage. (2) Convertase modulation; S. aureus inactivates the C3 convertases by secreting SCIN, SCIN-B, SCIN-C, Efb, and Ecb. (3) Modulating host regulators; Sbi and the streptococcal M-protein bind the negative convertase regulators (human FH, FHL1, C4BP, and CD46) while SpeB cleaves the positive convertase regulator, properdin
Localization (secreting) of SCIN in cleavage
4) Confidence 0.11 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0 Pain Relevance 0

General Comments

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