INT29971

Context Info Confidence 0.78 First Reported 1988 Last Reported 2010 Negated 7 Speculated 0 Reported most in Abstract Documents 126 Total Number 126 Disease Relevance 35.32 Pain Relevance 93.97

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)

Anatomy Link Frequency astrocytes 6 spinal cord 4 visceral 4 trigeminal ganglion 3 immune cell 3 Oprk1 (Mus musculus) Oprk1 - Y87F (1) Oprk1 - Y157F (1)

Pain Link Frequency Relevance Heat Opioid 2583 100.00 opioid receptor 1919 100.00 Kappa opioid receptor 1490 100.00 analgesia 1031 100.00 antinociception 676 100.00 agonist 508 100.00 Dynorphin 427 100.00 Analgesic 343 100.00 antagonist 310 100.00 narcan 120 100.00

Disease Link Frequency Relevance Heat Targeted Disruption 146 100.00 Neuropathic Pain 318 99.84 Thymoma 20 99.78 Lymphatic System Cancer 3 99.44 Nervous System Injury 174 99.36 Nociception 225 99.32 Ganglion Cysts 562 99.30 Pain 746 99.26 Anxiety Disorder 96 99.22 Hypoxia 16 99.16

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results show that KOR mRNA expression differs between PB+ and PB- groups of mice after nerve injury, and suggest an association of KOR expression with mechanical allodynia.

Gene_expression (expression) of KOR mRNA in nerve associated with nervous system injury, allodynia and kappa opioid receptor

1) Confidence 0.78 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.73 Pain Relevance 0.76

These results show that KOR mRNA expression differs between PB+ and PB- groups of mice after nerve injury, and suggest an association of KOR expression with mechanical allodynia.

Gene_expression (expression) of KOR in nerve associated with nervous system injury, allodynia and kappa opioid receptor

2) Confidence 0.78 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.72 Pain Relevance 0.74

Two groups of mice, both of them were subjected to unilateral transection of the inferior and superior caudal trunks at the S1spinal nerve, were compared with respect to KOR mRNA expression by reverse transcriptase-polymerase chain reaction.

Gene_expression (expression) of KOR mRNA in nerve associated with kappa opioid receptor

3) Confidence 0.78 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.60 Pain Relevance 0.72

The results indicate that a sulfhydryl group is present at or near the binding site on the kappa-opioid receptor expressed by the R1.1 thymoma cell line.

Gene_expression (expressed) of kappa-opioid receptor associated with thymoma and kappa opioid receptor

4) Confidence 0.77 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8206123 Disease Relevance 0.23 Pain Relevance 0.34

Studies were directed at determining whether the kappa-opioid receptor expressed on the mouse R1.1 thymoma cell line contained either a disulfide bond or a sulfhydryl group at the opioid binding site.

Gene_expression (expressed) of kappa-opioid receptor associated with thymoma, kappa opioid receptor and opioid

5) Confidence 0.77 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8206123 Disease Relevance 0.17 Pain Relevance 0.27

The kappa-opioid receptor expressed on the mouse lymphoma cell line R1.1 contains a sulfhydryl group at the binding site.

Gene_expression (expressed) of kappa-opioid receptor associated with lymphatic system cancer and kappa opioid receptor

6) Confidence 0.77 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 8206123 Disease Relevance 0.19 Pain Relevance 0.35

Double immunohistochemictry revealed that KOR-p-IR is expressed by astrocytes (GFAP) in TREZ of WT mice (Fig. 5G, H, I).

Gene_expression (expressed) of KOR-p-IR in astrocytes associated with kappa opioid receptor

7) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.34 Pain Relevance 0.96

KOR was constitutively expressed in postnatal day 19 (P19) embryonal carcinoma stem cells and is suppressed by NO donors [sodium nitroprusside (SNP), 3-morpholinosydnonimine-1, and S-nitrosoglutathione] in P19 stem cells within 4 hr.

Gene_expression (expressed) of KOR in stem cells associated with kappa opioid receptor and embryonal carcinoma

8) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.10 Pain Relevance 0.22

The results of the competitive RT/PCR indicated that CEM x174 cells expressed KOR mRNA constitutively, in the order of femto-grams.

Gene_expression (expressed) of KOR mRNA associated with kappa opioid receptor

9) Confidence 0.75 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727785 Disease Relevance 0.13 Pain Relevance 1.65

To determine whether morphine activates kappa opioid receptors (KOR), a quantitative competitive RT-PCR procedure was utilized to quantify the KOR gene expression of morphine-treated cells.

Gene_expression (expression) of KOR gene associated with kappa opioid receptor and morphine

10) Confidence 0.75 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727785 Disease Relevance 0.17 Pain Relevance 1.51

Treatment of 10 microM of morphine resulted in the up-regulation of KOR gene expression 24 hr post-treatment.

Gene_expression (expression) of KOR gene associated with kappa opioid receptor and morphine

11) Confidence 0.75 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727785 Disease Relevance 0.12 Pain Relevance 1.47

The data show that the enhanced antiexudative effects of KOR and DOR agonists could be related to an increased expression of KOR and DOR in the gut and that the release of nitric oxide may play a role augmenting the effects of opioids during chronic inflammation.

Gene_expression (expression) of KOR in gut associated with inflammation, agonist and opioid

12) Confidence 0.74 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16183704 Disease Relevance 0.56 Pain Relevance 0.82

The present study used a fluorescein-labeled arylacetamide (FITC-AA), a kappa opioid ligand, in conjunction with biotin-conjugated anti-fluorescein IgG and extravidin-R-phycoerythrin (PE), along with double-labeling with antibodies against specific immune cell surface markers to determine which subpopulation(s) of thymocytes express the kappa opioid receptor.

Gene_expression (express) of kappa opioid receptor in thymocytes associated with kappa opioid receptor and opioid

13) Confidence 0.71 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9435191 Disease Relevance 0.08 Pain Relevance 0.40

Therefore, these findings demonstrate that the thymocytes, which express the kappa opioid receptor, are predominantly of the immature CD4+/CD8+ phenotype.

Gene_expression (express) of kappa opioid receptor in thymocytes associated with kappa opioid receptor

14) Confidence 0.71 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9435191 Disease Relevance 0 Pain Relevance 0.54

A regulatory variation in OPRK1, the gene encoding the ?

Gene_expression (variation) of OPRK1

15) Confidence 0.68 Published 2008 Journal Human Molecular Genetics Section Title Doc Link PMC2405904 Disease Relevance 0.31 Pain Relevance 0.32

The OPRK1 5?

Gene_expression (The) of OPRK1

16) Confidence 0.68 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.31 Pain Relevance 0.15

Thus, buprenorphine is a potent kappa-opioid receptor antagonist, producing the kappa-antagonist activity over the same dose range that it produces its mu-mediated partial agonist activity.

Gene_expression (producing) of kappa-opioid receptor associated with antagonist, agonist, kappa opioid receptor and buprenorphine

17) Confidence 0.68 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2850923 Disease Relevance 0 Pain Relevance 1.33

It has been shown that the behavioural responses to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR).

Neg (lacking) Gene_expression (lacking) of KOR in visceral associated with targeted disruption, nociception and kappa opioid receptor

18) Confidence 0.67 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18643891 Disease Relevance 0.27 Pain Relevance 0.50

It has been shown that the behavioural responses to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR).

Neg (lacking) Gene_expression (lacking) of kappa-opioid receptor in visceral associated with targeted disruption, nociception and kappa opioid receptor

19) Confidence 0.67 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18643891 Disease Relevance 0.27 Pain Relevance 0.50

KOR was constitutively expressed in postnatal day 19 (P19) embryonal carcinoma stem cells and is suppressed by NO donors [sodium nitroprusside (SNP), 3-morpholinosydnonimine-1, and S-nitrosoglutathione] in P19 stem cells within 4 hr.

Gene_expression (expressed) of KOR in stem cells associated with kappa opioid receptor and embryonal carcinoma

20) Confidence 0.66 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.10 Pain Relevance 0.22

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