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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (APC, CTLA4) Golgi apparatus (CTLA4) protein complex assembly (APC)
cytoplasm (APC) cytosol (APC) chromosome organization (APC)
Anatomy Link Frequency
T cells 2
APC (Homo sapiens)
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 95.08 Very High Very High Very High
psoriasis 2 64.28 Quite High
rheumatoid arthritis 32 56.32 Quite High
Inflammation 9 49.28 Quite Low
abatacept 10 48.64 Quite Low
methotrexate 2 39.52 Quite Low
Arthritis 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 181 93.20 High High
Renal Cancer 5 81.08 Quite High
Infection 3 76.24 Quite High
Psoriasis 2 64.28 Quite High
Opportunistic Infections 1 62.20 Quite High
Rheumatoid Arthritis 32 56.32 Quite High
Apoptosis 1 52.72 Quite High
Carcinoma 2 50.00 Quite Low
INFLAMMATION 10 49.28 Quite Low
Melanoma 4 27.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently suggested that ligation of CTLA4–Ig with CD80/86 on the APC leads to activation of the enzyme IDO (indoleamine-2,3-oxygenase); this enzyme has the potential to modulate the function of the APC similar to that which has been proposed to occur after interaction of APCs with regulatory CD25+CD4+ T cells [55,56].
APC Binding (ligation) of CTLA4 in T cells
1) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.26 Pain Relevance 0.11
An example is CTLA-4, a negative regulator of T-cell activation, which is expressed on the T-cells and, like its homolog CD28, binds to B7 on the surface of the APC.
APC Binding (binds) of CTLA-4 in T-cells
2) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.71 Pain Relevance 0

General Comments

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