INT299766

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (APCS) protein folding (APCS) extracellular space (APCS)
extracellular region (APCS) protein complex (APCS)
Anatomy Link Frequency
T cells 2
APCS (Homo sapiens)
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 32 87.08 High High
Inflammation 8 82.56 Quite High
abatacept 10 76.44 Quite High
psoriasis 2 60.68 Quite High
cytokine 4 30.32 Quite Low
Arthritis 4 30.32 Quite Low
methotrexate 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 17 98.94 Very High Very High Very High
Rheumatoid Arthritis 32 87.08 High High
INFLAMMATION 9 82.56 Quite High
Psoriasis 2 60.68 Quite High
Arthritis 2 30.32 Quite Low
Immunization 1 28.84 Quite Low
Lymphoproliferative Disease 1 20.00 Low Low
Targeted Disruption 1 17.08 Low Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that T cells in patients with active disease have strong potential to interact with and activate APCs, which in turn upregulate their CD80 and CD86 expression and activate more T cells.
APCs Positive_regulation (upregulate) of Gene_expression (expression) of CD80 in T cells associated with disease
1) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.86 Pain Relevance 0.50

General Comments

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