INT299785

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CTLA4, CD28) cytosol (CD28) Golgi apparatus (CTLA4)
Anatomy Link Frequency
CD86 2
T-cell 2
CTLA4 (Homo sapiens)
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 2 99.56 Very High Very High Very High
psoriasis 4 91.12 High High
rheumatoid arthritis 57 89.56 High High
cytokine 28 64.12 Quite High
Inflammation 68 62.08 Quite High
Arthritis 14 40.76 Quite Low
methotrexate 17 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
Etanercept 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 66 98.68 Very High Very High Very High
Vasculitis 60 98.44 Very High Very High Very High
Psoriasis 4 91.12 High High
Rheumatoid Arthritis 57 89.56 High High
Systemic Lupus Erythematosus 7 88.56 High High
Adhesions 7 86.24 High High
Graft Vs Host Disease 1 84.08 Quite High
Urological Neuroanatomy 17 83.12 Quite High
Organ Transplantation 1 83.00 Quite High
Glomerulonephritis 10 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because CD152 has a high affinity for CD80 and CD86, soluble forms of CTLA4 inhibit the interaction of CD28 with its ligands.
CTLA4 Negative_regulation (inhibit) of CD28 Neg (inhibit) Binding (interaction) of in CD86
1) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.77 Pain Relevance 0.32
Abatacept, a fusion protein of CTLA4-Ig which selectively modulates T-cell co-stimulation by blocking the engagement of CD28, would theoretically be of benefit in AAV, although the EUVAS ABAVAS trial was terminated early due to slow recruitment.
CTLA4-Ig Negative_regulation (blocking) of CD28 Binding (engagement) of in T-cell associated with abatacept and vasculitis
2) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.03 Pain Relevance 0.18

General Comments

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