INT299789

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (RAE1) small molecule metabolic process (RAE1) carbohydrate metabolic process (RAE1)
transmembrane transport (RAE1) cytoplasm (RAE1) extracellular space (IL4)
Anatomy Link Frequency
B cells 2
IL4 (Homo sapiens)
RAE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 53 99.28 Very High Very High Very High
cytokine 24 96.48 Very High Very High Very High
Arthritis 13 84.24 Quite High
metalloproteinase 2 84.00 Quite High
Inflammation 62 80.88 Quite High
psoriasis 4 64.80 Quite High
corticosteroid 1 13.68 Low Low
tolerance 4 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 53 99.28 Very High Very High Very High
Hypercalcemia 1 91.24 High High
Arthritis 13 84.24 Quite High
INFLAMMATION 59 80.88 Quite High
Autoimmune Disease 17 78.84 Quite High
Experimental Autoimmune Encephalomyelitis 2 73.16 Quite High
Psoriasis 4 64.80 Quite High
Disease 24 22.40 Low Low
Cancer 5 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, IL-4 downregulates the surface expression of CD5 on B cells and inhibits spontaneous Ig and IgM rheumatoid factor production in patients with RA [77].
IL-4 Negative_regulation (inhibits) of Gene_expression (production) of IgM rheumatoid factor in B cells associated with rheumatoid arthritis
1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.84 Pain Relevance 0.41

General Comments

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