INT299791

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD28, CTLA4) cytosol (CD28) Golgi apparatus (CTLA4)
Anatomy Link Frequency
CD86 2
CD28 (Homo sapiens)
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 1 95.12 Very High Very High Very High
psoriasis 4 91.12 High High
rheumatoid arthritis 53 87.52 High High
Inflammation 62 62.08 Quite High
Arthritis 13 40.76 Quite Low
cytokine 24 36.16 Quite Low
tolerance 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 4 91.12 High High
Rheumatoid Arthritis 53 87.52 High High
Adhesions 4 86.24 High High
Graft Vs Host Disease 1 84.08 Quite High
Organ Transplantation 1 83.00 Quite High
Immune System Diseases 2 68.00 Quite High
INFLAMMATION 59 62.08 Quite High
Disease 24 48.16 Quite Low
Autoimmune Disease 17 43.44 Quite Low
Arthritis 13 40.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because CD152 has a high affinity for CD80 and CD86, soluble forms of CTLA4 inhibit the interaction of CD28 with its ligands.
Negative_regulation (inhibit) of CD28 Neg (inhibit) Binding (interaction) of CTLA4 in CD86
1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.77 Pain Relevance 0.32

General Comments

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