INT299800

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
plasma 2
macrophages 2
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 56 99.96 Very High Very High Very High
methotrexate 1 91.12 High High
Leflunomide 1 80.12 Quite High
Pain 1 79.52 Quite High
Inflammation 62 64.40 Quite High
rheumatoid arthritis 53 57.44 Quite High
Arthritis 13 30.00 Quite Low
tolerance 4 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leishmaniasis 33 84.84 Quite High
Weight Loss 1 76.76 Quite High
Anaemia 1 76.12 Quite High
Fever 3 74.44 Quite High
Autoimmune Disease 17 73.40 Quite High
Disease 34 72.36 Quite High
Recurrence 22 71.04 Quite High
INFLAMMATION 59 64.40 Quite High
Rheumatoid Arthritis 53 57.44 Quite High
Arthritis 13 30.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, pretreatment of macrophages with sulfasalazine either in vitro or in vivo reduces their ability to induce the Th1 cytokine IFN-?
Negative_regulation (reduces) of Positive_regulation (induce) of Th1 in macrophages associated with cytokine
1) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.32 Pain Relevance 0.27
Successfully cured patients showed reduced IL-12 and IL-10 levels in the plasma and two-fold or more increase in Th1 type-cytokines IFN-?
Negative_regulation (reduced) of Positive_regulation (increase) of Th1 in plasma associated with cytokine
2) Confidence 0.16 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.73 Pain Relevance 0.17

General Comments

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