INT299801

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD58) plasma membrane (CD58)
Anatomy Link Frequency
hinge 2
CD58 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 124 91.68 High High
psoriasis 8 90.24 High High
rheumatoid arthritis 106 81.44 Quite High
Arthritis 26 80.24 Quite High
abatacept 2 24.24 Low Low
cytokine 48 16.36 Low Low
tolerance 8 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 118 91.68 High High
Psoriasis 8 90.24 High High
Disease 48 87.64 High High
Autoimmune Disease 34 82.92 Quite High
Rheumatoid Arthritis 106 81.44 Quite High
Arthritis 26 80.24 Quite High
Adhesions 8 68.84 Quite High
Organ Transplantation 2 67.76 Quite High
Graft Vs Host Disease 2 65.92 Quite High
Rheumatic Diseases 4 47.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
Negative_regulation (blocked) of CD58 in hinge
1) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.83 Pain Relevance 0.23
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
Negative_regulation (domain) of CD58 in hinge
2) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.83 Pain Relevance 0.23

General Comments

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