INT299802

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 7 90.48 High High
cytokine 44 88.28 High High
psoriasis 59 78.24 Quite High
Leflunomide 1 64.12 Quite High
Inflammation 98 62.80 Quite High
rheumatoid arthritis 53 57.44 Quite High
Arthritis 26 14.00 Low Low
Etanercept 17 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 72 99.52 Very High Very High Very High
INFLAMMATION 95 62.80 Quite High
Rheumatoid Arthritis 53 57.44 Quite High
Autoimmune Disease 21 57.40 Quite High
Arthritis 14 14.00 Low Low
Rheumatic Diseases 2 10.88 Low Low
Disease 55 5.00 Very Low Very Low Very Low
Infection 28 5.00 Very Low Very Low Very Low
Demyelinating Disease 17 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, clinical efficacy of cyclosporine is associated with decreased serum levels of IFN-?
Negative_regulation (decreased) of Transcription (levels) of IFN
1) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.23 Pain Relevance 0.30
Of the 17 subjects who received the IL-12/23 monoclonal antibody, 13 (76%) achieved PASI 75, compared with no placebo subjects. mRNA expression of IL-12, IL-23, IL-8, IL-18, and IFN-?
Negative_regulation (achieved) of Neg (no) Transcription (expression) of IFN
2) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.31 Pain Relevance 0.11

General Comments

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