INT299853

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.05
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Crybb2)
Anatomy Link Frequency
lens 1
lens fiber 1
Crybb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 43 86.92 High High
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 248 96.08 Very High Very High Very High
Stress 11 91.12 High High
INFLAMMATION 43 86.92 High High
Injury 3 85.68 High High
Diabetic Retinopathy 68 85.20 High High
Shock 4 79.36 Quite High
Apoptosis 20 64.96 Quite High
Disease 4 60.04 Quite High
Adhesions 7 54.76 Quite High
Blindness 8 46.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As we know, the loss of Pax6 expression in lens fiber cells is essential for normal fiber cell differentiation and crystallin gene expression [5].
Gene_expression (expression) of crystallin gene in lens fiber
1) Confidence 0.68 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
During lens development, the morphological transition between epithelial cells and fiber cells coincides with specific, regulated changes in crystallin gene expression.
Gene_expression (expression) of crystallin gene in lens
2) Confidence 0.68 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0.28 Pain Relevance 0.03
In an independent experiment, insulin replacement therapy normalized the expression of some proteins (Dbi, Anxa5) while other proteins (Cp, Cryba3, Lgals3, Stat3) were only partially normalized and Fgf2 and Crybb2 expression remained elevated.


Gene_expression (expression) of Crybb2
3) Confidence 0.67 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020973 Disease Relevance 0.41 Pain Relevance 0.04
Crybb2 protein expression was not normalized by insulin treatment, while Cryba3 protein expression was partially normalized.
Gene_expression (expression) of Crybb2 protein
4) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.45 Pain Relevance 0
All mammals examined to date have three major crystallin gene families: ?
Gene_expression (families) of crystallin gene
5) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0.21 Pain Relevance 0.03
Interestingly, Cryba3 protein expression was only partially normalized by insulin treatment and Crybb2 protein expression was unaffected.
Gene_expression (expression) of Crybb2 protein
6) Confidence 0.58 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.70 Pain Relevance 0
Two patterns of expression were evident with one set of proteins regulated at both the transcript and protein levels (Cp, Lgals3, Fgf2, and Stat3) (Figure 5) and another set with altered protein expression but no significant changes in transcript expression (Cryaa, Cryab, Cryba3, Crybb2, Dbi, and Anxa5) (Figure 6).
Gene_expression (expression) of Crybb2
7) Confidence 0.52 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0 Pain Relevance 0

General Comments

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