INT29986

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Context Info
Confidence 0.27
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.34
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 15 97.74 Very High Very High Very High
Inflammation 112 96.44 Very High Very High Very High
opioid receptor 1 75.00 Quite High
cytokine 39 73.12 Quite High
chemokine 34 72.24 Quite High
Delta opioid receptors 1 63.44 Quite High
tolerance 2 54.40 Quite High
qutenza 2 50.00 Quite Low
lidocaine 1 37.16 Quite Low
Inflammatory response 3 30.96 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 197 99.60 Very High Very High Very High
Eczema 5 98.32 Very High Very High Very High
Rhinitis 14 97.86 Very High Very High Very High
Asthma 32 97.48 Very High Very High Very High
Disease 118 97.18 Very High Very High Very High
INFLAMMATION 114 96.44 Very High Very High Very High
Lymphatic System Cancer 83 94.72 High High
Chronic Lymphoid Leukemia 14 89.32 High High
Hemorrhage 1 84.68 Quite High
Increased Venous Pressure Under Development 2 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, our data showed that neonatal capsaicin treatment did not interfere with either IgG1 or IgE production.
IgE Neg (not) Binding (interfere) of
1) Confidence 0.27 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11549890 Disease Relevance 0 Pain Relevance 0
Antibodies targeting CD19, CD20, CD22, in combination with a toxin, CD23, CD40, CD80, and HLA-DR are being evaluated in clinical trials, and their additional benefit will be evaluated in coming years (DiJoseph et al 2004, 2006; Byrd et al 2005; Czuczman et al 2005; Foreno-Torres et al 2006).
CD23 Binding (targeting) of
2) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 1.22 Pain Relevance 0
Biotinylated anti-mouse IgE (R35-118; BD PharMingen, San Diego, USA) was added to the wells at 2 ?
IgE Binding (added) of
3) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.06 Pain Relevance 0.03
To measure HDM-specific IgE, the plate was coated with 25 ?
IgE Binding (coated) of
4) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0 Pain Relevance 0
It has been reported that IgE-mediated inflammation to mites is associated with diseases such as asthma, allergic rhinitis, and atopic dermatitis and that the relatively minor determinants of house dust mite (HDM) allergens show IgE binding with 40% or more of allergic sera [1-4].
IgE Binding (binding) of associated with asthma, rhinitis, inflammation, hypersensitivity, eczema and disease
5) Confidence 0.03 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.98 Pain Relevance 0.12
BD Falcon Microtest™ plates (BD Falcon, Franklin Lakes, NJ) were coated with rat anti-mouse IgG1 (A85-3), IgE (R35-72) (BD PharMingen) or goat anti-mouse IgA (Southern Biotechnology Associates), at 2 ?
IgE Binding (coated) of
6) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0 Pain Relevance 0
In an immediate early phase allergic reaction, Immunoglobulin E (IgE) bound to Fc?
IgE Binding (bound) of associated with hypersensitivity
7) Confidence 0.01 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 1.75 Pain Relevance 0.09
Antigen-mediated cross-linking of surface IgE/Fc?
IgE Binding (linking) of
8) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.33 Pain Relevance 0.10
These results suggest that, for [D-Pen2, D-Pen5]enkephalin, adverse steric interactions between the D-Pen2 pro-R methyl group and the mu receptor binding site lead to the low mu receptor binding affinity observed for this analog.
low mu receptor Binding (affinity) of associated with enkephalin
9) Confidence 0.00 Published 1988 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2851561 Disease Relevance 0 Pain Relevance 1.03

General Comments

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