INT299866

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.12
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prox1) DNA binding (Prox1) molecular_function (Prox1)
cytoplasm (Prox1)
Anatomy Link Frequency
lens 3
capsule 2
endothelial cells 1
retina 1
lens fiber 1
Prox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 10 65.32 Quite High
Inflammation 69 51.96 Quite High
Inflammatory response 30 5.00 Very Low Very Low Very Low
ketamine 22 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
dexamethasone 11 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 8 98.92 Very High Very High Very High
Liver Disease 20 95.28 Very High Very High Very High
Gallstones 16 93.64 High High
Hypoalbuminemia 1 93.56 High High
Lymphatic System Cancer 1 93.04 High High
Enteropathy 7 85.24 High High
Gastrointestinal Disease 4 81.32 Quite High
Hypertension 38 80.60 Quite High
Pressure And Volume Under Development 119 75.44 Quite High
Intestinal Cancer 1 71.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the LECs of the anterior capsule, there was weak expression of Prox1 in the cytoplasm and dense expression in the nuclei (Figure 6G,H), while in the lens fiber cells, Prox1 protein was strictly expressed in nuclei.
Gene_expression (expressed) of Prox1 protein in capsule
1) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Prox1, a divergent homeodomain protein, is expressed initially in the early lens placode and is upregulated during fiber cell differentiation [15,16].
Gene_expression (expressed) of Prox1 in lens placode
2) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
In the LECs of the anterior capsule, there was weak expression of Prox1 in the cytoplasm and dense expression in the nuclei (Figure 6G,H), while in the lens fiber cells, Prox1 protein was strictly expressed in nuclei.
Gene_expression (expression) of Prox1 in capsule
3) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Prox1 protein was also expressed in the inner nuclear layer of the retina (data not shown).
Gene_expression (expressed) of Prox1 protein in retina
4) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Real-time PCR and/or immunofluorescence were performed to detect the expression of the lens transcription factors paired box 6 (Pax6), prospero homeobox 1 (Prox1), and forkhead box E3 (Foxe3) and ?
Gene_expression (expression) of Prox1 in lens
5) Confidence 0.59 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
From then on, the relative expression quantity of Prox1 increased slowly until 3 months after ECLE. mRNA expression of Pax6 increased gradually following ECLE, peaking at 1 month and decreasing obviously at 3 months.
Gene_expression (expression) of Prox1
6) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Three days after surgery, the mRNA expression of Prox1 increased significantly.
Gene_expression (expression) of Prox1
7) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Fourteen days after ECLE, the mRNA expression of Prox1 was less than that at 3 days after ECLE.
Gene_expression (expression) of Prox1
8) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
The relative expression quantities of Pax6 and Prox1 immediately after ECLE decreased noticeably as visualized by real-time PCR, shown in Figure 8.
Gene_expression (expression) of Prox1
9) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Generation of the Prox1 null allele in mice reveals that this transcription factor is essential for the differentiation of lens fiber cells.
Gene_expression (Generation) of Prox1 in lens fiber
10) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Real-time PCR and/or immunofluorescence were performed to detect the expression of the lens transcription factors paired box 6 (Pax6), prospero homeobox 1 (Prox1), and forkhead box E3 (Foxe3) and ?
Gene_expression (expression) of prospero homeobox 1 in lens
11) Confidence 0.51 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Using the transcription factor Prox 1, expressed in lymphatic endothelial cells, as a marker of lymphangiogenesis [130, 131], we have shown that in the intestinal mucosa/submucosa of rats with microsurgical cholestasis, a lymphatic hyperplasia is produced (unpublished results) (Figure 6).
Gene_expression (expressed) of factor Prox 1 in endothelial cells associated with lymphatic system cancer and gallstones
12) Confidence 0.06 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 1.12 Pain Relevance 0.06

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