INT299869

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Crybb2)
Anatomy Link Frequency
lens 2
Crybb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 86.92 High High
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
GABAergic 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 62 89.84 High High
INFLAMMATION 11 86.92 High High
Injury 1 86.12 High High
Stress 3 73.28 Quite High
Diabetic Retinopathy 17 62.48 Quite High
Adhesions 2 55.20 Quite High
Apoptosis 5 53.20 Quite High
Blindness 2 46.20 Quite Low
Capsule Opacification 6 5.00 Very Low Very Low Very Low
Cataract 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During lens development, the morphological transition between epithelial cells and fiber cells coincides with specific, regulated changes in crystallin gene expression.
Positive_regulation (changes) of Gene_expression (expression) of crystallin gene in lens
1) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0.28 Pain Relevance 0.03
In an independent experiment, insulin replacement therapy normalized the expression of some proteins (Dbi, Anxa5) while other proteins (Cp, Cryba3, Lgals3, Stat3) were only partially normalized and Fgf2 and Crybb2 expression remained elevated.


Positive_regulation (elevated) of Gene_expression (expression) of Crybb2
2) Confidence 0.43 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020973 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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