INT299874

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.27
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Crybb2)
Anatomy Link Frequency
lens 4
Crybb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 22 68.72 Quite High
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
GABAergic 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 124 96.08 Very High Very High Very High
Stress 6 92.32 High High
Injury 2 86.52 High High
Diabetic Retinopathy 34 86.40 High High
Shock 2 80.56 Quite High
INFLAMMATION 22 68.72 Quite High
Apoptosis 10 66.16 Quite High
Disease 2 60.04 Quite High
Adhesions 4 55.60 Quite High
Ganglion Cysts 4 27.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Cryba3 protein expression was only partially normalized by insulin treatment and Crybb2 protein expression was unaffected.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of Crybb2 protein
1) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.71 Pain Relevance 0
During lens development, the morphological transition between epithelial cells and fiber cells coincides with specific, regulated changes in crystallin gene expression.
Regulation (changes) of Gene_expression (expression) of crystallin gene in lens
2) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0.28 Pain Relevance 0.03
During lens development, the morphological transition between epithelial cells and fiber cells coincides with specific, regulated changes in crystallin gene expression.
Regulation (regulated) of Gene_expression (expression) of crystallin gene in lens
3) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0.28 Pain Relevance 0.03
Two patterns of expression were evident with one set of proteins regulated at both the transcript and protein levels (Cp, Lgals3, Fgf2, and Stat3) (Figure 5) and another set with altered protein expression but no significant changes in transcript expression (Cryaa, Cryab, Cryba3, Crybb2, Dbi, and Anxa5) (Figure 6).
Neg (no) Regulation (changes) of Gene_expression (expression) of Crybb2
4) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0 Pain Relevance 0

General Comments

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