INT29988

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 5.45
Pain Relevance 9.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
visceral 1
paw 1
nerve 1
neurons 1
brain 1
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 708 100.00 Very High Very High Very High
Enkephalin 30 100.00 Very High Very High Very High
GABAergic 1 99.38 Very High Very High Very High
Inflammation 366 99.28 Very High Very High Very High
Serotonin 135 99.20 Very High Very High Very High
Spinal cord 61 98.62 Very High Very High Very High
Delta opioid receptors 2 98.30 Very High Very High Very High
IPN 108 97.68 Very High Very High Very High
Hippocampus 44 97.56 Very High Very High Very High
Raphe 3 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 43 99.92 Very High Very High Very High
INFLAMMATION 324 99.28 Very High Very High Very High
Nervous System Injury 21 99.12 Very High Very High Very High
Inflammatory Pain 108 97.68 Very High Very High Very High
Stress 17 97.42 Very High Very High Very High
Death 21 95.92 Very High Very High Very High
Urological Neuroanatomy 1 95.64 Very High Very High Very High
Dyspepsia 20 95.04 Very High Very High Very High
Hypertrophy 21 95.00 High High
Pain 353 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data highlight GABAergic neurons as major target cells expressing Mecp2 in response to the serotonin-elevating agents and suggest that serotonin signaling enhances gene silencing in postmitotic neurons.
Gene_expression (expressing) of Mecp2 in GABAergic neurons associated with gabaergic and serotonin
1) Confidence 0.78 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16670375 Disease Relevance 0.15 Pain Relevance 0.66
Here, we found that a large population of P-MeCP2 immunopositive nuclei were also expressing Fos (82–90%) and Zif268 (76–78%).
Gene_expression (expressing) of P-MeCP2
2) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.40 Pain Relevance 0.57
Although the levels of P-MeCP2 and Zif268 seen 6 h after CFA were no different from that in naïve animals, there was a significant upregulation in the levels of P-MeCP2, Zif268 and Fos 24 h after CFA (increase to 21 ± 3 immunopositive nuclei (P < 0.01), 31 ± 8 immunopositive nuclei (P < 0.05) and 32 ± 1 (P < 0.01) respectively).


Gene_expression (levels) of P-MeCP2
3) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.07
A large population of neurones expressed both P-MeCP2 and Zif268, and P-MeCP2 and Fos (Figure 5A and 5B).
Gene_expression (expressed) of P-MeCP2
4) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.11
It seems likely that the expression of P-MeCP2, Zif268 and Fos is part of an early cascade of molecular events that lead to changes in gene expression required for both the initiation and maintenance of pain states.
Gene_expression (expression) of P-MeCP2 associated with pain
5) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.31 Pain Relevance 0.31
A large population of neurones expressed both P-MeCP2 and Zif268, and P-MeCP2 and Fos (Figure 5A and 5B).
Gene_expression (expressed) of P-MeCP2
6) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.11
Although the levels of P-MeCP2 and Zif268 seen 6 h after CFA were no different from that in naïve animals, there was a significant upregulation in the levels of P-MeCP2, Zif268 and Fos 24 h after CFA (increase to 21 ± 3 immunopositive nuclei (P < 0.01), 31 ± 8 immunopositive nuclei (P < 0.05) and 32 ± 1 (P < 0.01) respectively).


Gene_expression (levels) of P-MeCP2
7) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.10
Descending serotonergic inputs are essential for the full expression of P-MeCP2, Zif268 and Fos in the dorsal horn
Gene_expression (expression) of P-MeCP2 in dorsal horn associated with dorsal horn
8) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.13 Pain Relevance 0.17
However only 10% of NK1 expressing neurones expressed Fos, irrespectively of the noxious stimulation (skin, joint, muscle, inflammation and nerve injury) [31], strongly suggesting that Zif268 and P-MeCP2 are more generally expressed in NK1-positive projections neurones than Fos.
Gene_expression (expressed) of P-MeCP2 in nerve associated with nervous system injury and inflammation
9) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.43 Pain Relevance 0.48
Changes in P-MeCP2, Zif268 and Fos expression were quantified by immunohistochemistry.
Gene_expression (expression) of P-MeCP2
10) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.06 Pain Relevance 0.21
A decrease in expression of SIN3A, a corepressor in the MeCP2 silencing complex, was also found after inflammation.
Gene_expression (expression) of MeCP2 associated with inflammation
11) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553988 Disease Relevance 0.86 Pain Relevance 0.76
There was no significant difference in the levels of P-MeCP2 between 1 h and 2 h, nor of Zif268 or Fos.
Gene_expression (levels) of P-MeCP2
12) Confidence 0.66 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.07
P-MeCP2 is co-expressed in neurones with Zif268 and Fos
Gene_expression (expressed) of P-MeCP2
13) Confidence 0.66 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.10
Tissue was taken at 1 h and 2 h after CFA and sections were double-labelled for P-MeCP2 and Zif268, and P-MeCP2 and Fos (N = 2/4 in each group).
Gene_expression (double) of P-MeCP2
14) Confidence 0.66 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.08
Tissue was taken at 1 h and 2 h after CFA and sections were double-labelled for P-MeCP2 and Zif268, and P-MeCP2 and Fos (N = 2/4 in each group).
Gene_expression (double) of P-MeCP2
15) Confidence 0.66 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.08
We compared the expression of P-MeCP2 with that of Zif268 and Fos in laminae I-II across all time points (Figure 3 and Figure 4; N = 3/5 at each time point).
Gene_expression (expression) of P-MeCP2
16) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.09
We show that the activation or expression of the transcription factors MeCP2, Zif268 and Fos after primary afferents stimulation depend on convergent input from primary afferents and descending pathways from the brain.
Gene_expression (expression) of MeCP2 in brain
17) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.28 Pain Relevance 0.33
Interestingly, there was no difference in the ratio of P-MeCP2 neurones expressing Zif268 at 1 h and 2 h (78% ± 5% and 76% ± 5%, respectively) whereas the number of P-MeCP2 neurones expressing Fos increased slightly with time (82% ± 2% at 1 h and 90% ± 1% at 2 h, P < 0.05).


Gene_expression (expressing) of P-MeCP2
18) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.14
When animals received 5,7-DHT, there was a significant reduction compared with saline in expression of P-MeCP2 ipsilateral to the CFA injection (47 ± 4 vs 20 ± 2 immunopositive nuclei; F1,10 = 37, P < 0.001), Zif268 (121 ± 14 vs 76 ± 7; F1,10 = 11, P < 0.05) and Fos (81 ± 7 vs 59 ± 5; F1,10 = 8, P < 0.05) in laminae I-II (Figure 7A and 7B).
Gene_expression (expression) of P-MeCP2
19) Confidence 0.51 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.19 Pain Relevance 0.19
Interestingly, there was no difference in the ratio of P-MeCP2 neurones expressing Zif268 at 1 h and 2 h (78% ± 5% and 76% ± 5%, respectively) whereas the number of P-MeCP2 neurones expressing Fos increased slightly with time (82% ± 2% at 1 h and 90% ± 1% at 2 h, P < 0.05).


Gene_expression (expressing) of P-MeCP2
20) Confidence 0.51 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.10 Pain Relevance 0.16

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