INT299913

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgg) extracellular space (Fgg) extracellular region (Fgg)
protein binding, bridging (Fgg) molecular_function (Fgg) cellular_component (Fgg)
Fgg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 60 99.76 Very High Very High Very High
Coronary Artery Disease 78 99.04 Very High Very High Very High
Acute Coronary Syndrome 24 93.12 High High
Pathologic Constriction 9 92.04 High High
Obesity 6 82.88 Quite High
Myocardial Infarction 45 66.24 Quite High
Disorder Of Lipid Metabolism 12 59.20 Quite High
Nicotine Addiction 9 46.96 Quite Low
Diabetes Mellitus 15 46.48 Quite Low
Hypertension 15 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rs2070006 and rs2066865 SNPs in FGA and FGG genes respectively were nominally associated with increased risk of CAD both in the additive and dominant models of inheritance, but statistical significance was lost after adjustment.
FGG Binding (associated) of associated with coronary artery disease
1) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2834581 Disease Relevance 0.86 Pain Relevance 0
No other SNP in FGA, FGB and FGG genes was associated with disease occurrence.
FGG Binding (associated) of associated with disease
2) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2834581 Disease Relevance 0.49 Pain Relevance 0
Haplotype analysis showed that when FGA and FGG gene SNPs were considered together, FGA-FGG-H3 haplotype TGATTA bearing the minor alleles of both rs2070006 and rs2066865 SNPs was associated with an increase in disease risk in the unadjusted analysis, but after adjustment this association disappeared.
FGG Binding (associated) of associated with disease
3) Confidence 0.24 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2834581 Disease Relevance 0.92 Pain Relevance 0

General Comments

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