INT299964

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 7.32
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (FTSJ3) nucleolus (FTSJ3) nucleus (FTSJ3)
Anatomy Link Frequency
bridge 1
bone marrow 1
FTSJ3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 52 99.68 Very High Very High Very High
antagonist 13 97.28 Very High Very High Very High
agonist 78 91.36 High High
depression 13 76.84 Quite High
Inflammation 78 64.52 Quite High
cytokine 13 19.68 Low Low
Nicotine 52 5.00 Very Low Very Low Very Low
Angina 26 5.00 Very Low Very Low Very Low
Bioavailability 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 78 99.68 Very High Very High Very High
Coronary Artery Disease 351 99.28 Very High Very High Very High
Stress 65 99.00 Very High Very High Very High
Death 52 98.40 Very High Very High Very High
Adhesions 13 98.00 Very High Very High Very High
Atherosclerosis 91 97.84 Very High Very High Very High
Myocardial Infarction 299 97.00 Very High Very High Very High
Pathologic Constriction 52 94.12 High High
Aging 39 91.92 High High
Pressure And Volume Under Development 26 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, increases in the functional activity of EPCs - as assessed by their proliferation, migration, adhesion and in vitro vasculogenesis capacity - was also seen.
Positive_regulation (increases) of EPCs associated with adhesions
1) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.45 Pain Relevance 0.13
Min et al showed that treatment with ramipril 5 mg daily for 4 weeks in patients with CAD was associated with an approximately 1.5-fold increase in the number of circulating EPCs within 1 week of initiating treatment [33].
Positive_regulation (increase) of EPCs associated with coronary artery disease
2) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.38 Pain Relevance 0.08
In contrast, Guven et al [43] showed that the number of EPCs was increased among patients with significant CAD especially in those requiring coronary intervention, and EPC numbers correlated with the maximum angiographic stenosis severity.
Positive_regulation (increased) of EPCs associated with pathologic constriction and coronary artery disease
3) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.16 Pain Relevance 0.08
Statin therapy is associated with an increase in the number of circulating EPCs in patients with CAD [20] (Table 3).
Positive_regulation (increase) of EPCs associated with coronary artery disease
4) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.23 Pain Relevance 0.03
The increase in EPCs and improvement of their migratory capacity was significant as early as at 1 week after the initiation of treatment with atorvastatin, with a 3-fold increase at 3 to 4 weeks of therapy [20].
Positive_regulation (increase) of EPCs
5) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.23 Pain Relevance 0.03
Angiotensin II subtype 1-receptor blockade increases the number of EPCs, an effect which seems to be common to all angiotensin II receptor antagonists [75].
Positive_regulation (increases) of EPCs associated with antagonist
6) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.35 Pain Relevance 0.09
After adjustment for age, sex, vascular risk factors and other relevant variables, increased levels of EPCs were associated with a reduced risk of death from cardiovascular causes, a first major cardiovascular event, revascularization and hospitalization.
Positive_regulation (increased) of EPCs associated with death
7) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.95 Pain Relevance 0.08
Physiological factors and conventional risk factors for atherosclerosis are associated with variations of the number and activity of endothelial progenitors and may be the bridge linking EPCs to common cardiovascular disorders such as coronary artery disease (CAD), myocardial infarction and heart failure.
Positive_regulation (linking) of EPCs in bridge associated with coronary artery disease, atherosclerosis and myocardial infarction
8) Confidence 0.06 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.79 Pain Relevance 0
Indeed, CD34 or CD133 and alone or in different combinations (often with KDR) are the most popular markers used to define 'circulating EPCs'.
Positive_regulation (circulating) of EPCs
9) Confidence 0.06 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.11 Pain Relevance 0
Jie et al analysed the number of circulating CD34+/KDR+ EPCs in healthy subjects aged from 1 to 81 years old, and an inverse relationship with age was observed [10].
Positive_regulation (circulating) of EPCs
10) Confidence 0.06 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.76 Pain Relevance 0
Measurement of EPCs is of predictive value for cardiovascular outcomes in stable CAD patients.
Positive_regulation (Measurement) of EPCs associated with coronary artery disease
11) Confidence 0.06 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.08 Pain Relevance 0.10
Enalapril also caused a 6-fold increase in the contribution of bone marrow-derived EPCs to the ischemia-induced neovascularization.


Positive_regulation (increase) of EPCs in bone marrow associated with ischemia
12) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.41 Pain Relevance 0.22
Broadly similar effects were also seen with enalapril, as shown in a study by Wang et al, whereby patients on enalapril displayed a significant increase in circulating EPCs in response to ischemic stress [76].
Positive_regulation (increase) of EPCs associated with stress
13) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.41 Pain Relevance 0.15

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