INT299965

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.44
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EPC1) nucleus (EPC1)
Anatomy Link Frequency
bone marrow 1
Stem 1
EPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 29 97.68 Very High Very High Very High
cytokine 11 93.80 High High
Bioavailability 14 92.88 High High
Angina 14 88.16 High High
Inflammation 43 86.16 High High
depression 7 48.32 Quite Low
agonist 42 5.00 Very Low Very Low Very Low
Nicotine 28 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 14 99.76 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

7 99.20 Very High Very High Very High
Cardiovascular Disorder Under Development 28 98.78 Very High Very High Very High
Stress 35 98.60 Very High Very High Very High
Cv Unclassified Under Development 43 97.68 Very High Very High Very High
Apoptosis 15 95.52 Very High Very High Very High
Myocardial Infarction 164 95.48 Very High Very High Very High
Disorder Of Lipid Metabolism 7 94.88 High High
Coronary Artery Disease 189 94.40 High High
Cv General 3 Under Development 14 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, physical activity positively affects both bone marrow and peripheral EPC levels [15].
Regulation (affects) of EPC in bone marrow
1) Confidence 0.23 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.54 Pain Relevance 0.03
Of note, the type of revascularization (ie, thrombolytic therapy or primary angioplasty) does not seem to affect EPC mobilization [50].
Spec (seem) Regulation (affect) of EPC
2) Confidence 0.23 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.12 Pain Relevance 0.24
The number of circulating CD133+ or CD34+/KDR+ EPCs and EPC function estimated by proliferation of CFU-ECs inversely correspondent with the degree of endothelial function impairment [44].
Regulation (circulating) of EPC
3) Confidence 0.19 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.85 Pain Relevance 0.12
Indeed, there is a biphasic effect of statins on EPC counts.
Regulation (effect) of EPC
4) Confidence 0.17 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.25 Pain Relevance 0
Given that CD34 and CD133 are also markers of EPC [25], we sought to examine whether Stem-Kine affected EPC levels in the periphery.
Spec (whether) Regulation (affected) of EPC in Stem
5) Confidence 0.11 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0 Pain Relevance 0.05
So far, EPCs have been implicated in the whole cardiovascular disease process, and many conventional therapies have been shown to alter EPC number and function.
Regulation (alter) of EPC associated with cardiovascular disorder under development
6) Confidence 0.10 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.23 Pain Relevance 0
Hypercholesterolemia negatively affects both EPC number and function.
Regulation (affects) of EPC associated with hyperlipidemia
7) Confidence 0.10 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.68 Pain Relevance 0.05
Enhanced oxidative stress associated with dyslipidaemia may at least be partly involved in the dysregulation of EPC mobilisation, maturation and survival.
Regulation (dysregulation) of EPC associated with stress
8) Confidence 0.10 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.59 Pain Relevance 0.04

General Comments

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