INT299967

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 11.72
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (FTSJ3) nucleolus (FTSJ3) nucleus (FTSJ3)
Anatomy Link Frequency
CECs 1
FTSJ3 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 13 100.00 Very High Very High Very High
Nicotine 52 98.92 Very High Very High Very High
Bioavailability 26 98.32 Very High Very High Very High
Inflammation 78 91.76 High High
cytokine 13 81.84 Quite High
Angina 26 79.48 Quite High
ischemia 52 79.12 Quite High
antagonist 13 46.64 Quite Low
agonist 78 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 13 100.00 Very High Very High Very High
Disease Progression 26 99.96 Very High Very High Very High
Coronary Artery Disease 351 99.78 Very High Very High Very High
Pressure And Volume Under Development 26 99.64 Very High Very High Very High
Disease 39 99.60 Very High Very High Very High
Nicotine Addiction 91 99.58 Very High Very High Very High
Atherosclerosis 91 99.32 Very High Very High Very High
Neointima 39 99.24 Very High Very High Very High
Hyperplasia 26 98.84 Very High Very High Very High
Diabetes Mellitus 65 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion in EPCs has been correlated with high levels of TNF-?
Negative_regulation (Depletion) of EPCs
1) Confidence 0.07 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.18 Pain Relevance 0.20
Indeed, the number of EPCs is reduced in chronic smokers, whilst cessation of smoking leads to rapid restoration of EPC levels [32].
Negative_regulation (number) of EPCs associated with nicotine addiction
2) Confidence 0.07 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.85 Pain Relevance 0.18
These observations were further substantiated by Deschaseaux et al [74], who demonstrated that statin-induced depression of EPCs was only attributed to CFU-ECs, whereas the ECFC populations, were preserved or even enhanced in the circulation by long-term statin treatment.
Negative_regulation (depression) of EPCs associated with depression
3) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.31 Pain Relevance 0.05
Indeed, the number of EPCs is reduced in chronic smokers, whilst cessation of smoking leads to rapid restoration of EPC levels [32].
Negative_regulation (reduced) of EPCs associated with nicotine addiction
4) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.85 Pain Relevance 0.18
Since atherosclerotic risk factors are associated with reduced numbers and function of circulating EPCs, it is possible that progression of atherosclerosis is 'driven' by an impairment of EPC repairing capacity [9].
Negative_regulation (reduced) of EPCs associated with atherosclerosis
5) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.94 Pain Relevance 0.04
In contrast, Guven et al [43] showed that the number of EPCs was increased among patients with significant CAD especially in those requiring coronary intervention, and EPC numbers correlated with the maximum angiographic stenosis severity.
Negative_regulation (number) of EPCs associated with pathologic constriction and coronary artery disease
6) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.16 Pain Relevance 0.08
In contrast to the data where increased numbers of EPCs lead to excessive neointima hyperplasia, Matsuo et al have demonstrated that circulating EPCs in patients with in-stent restenosis grow less colonies of CFU-ECs and these cells have signs of increased senescence compared to patients with successful arterial healing [68].
Negative_regulation (numbers) of EPCs associated with aging, cardiovascular disease, neointima and hyperplasia
7) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.85 Pain Relevance 0
An inverse relationship has been found between EPCs and CECs, as elevated numbers of CECs have been seen in patients with CAD whereas a reduction in the number of circulating EPCs has been associated with CAD [39-41].


Negative_regulation (reduction) of EPCs in CECs associated with coronary artery disease
8) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.24 Pain Relevance 0.03
For example, smoking contributes towards reducing the number of circulating EPCs, whilst hypertension reduces migratory capacity [9].
Negative_regulation (reducing) of EPCs associated with pressure and volume under development and nicotine addiction
9) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.81 Pain Relevance 0
Reduced levels of EPCs have been described in both type 1 and type 2 diabetes mellitus [26].
Negative_regulation (Reduced) of EPCs associated with diabetes mellitus
10) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.81 Pain Relevance 0.03
Multivariate analysis showed that the number of EPCs predicted severe endothelial dysfunction independently of classical cardiovascular risk factors.


Negative_regulation (number) of EPCs
11) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.88 Pain Relevance 0.08
Reduced levels of circulating EPCs have been shown to be independent predictors of atherosclerotic disease progression [37].
Negative_regulation (Reduced) of EPCs associated with atherosclerosis and disease progression
12) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.10 Pain Relevance 0.05
The effect of physical activity on EPCs may be reduced by inhibition of endogenous NO synthase [20].


Negative_regulation (reduced) of EPCs
13) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.60 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox