INT29997

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.32
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
PGE2 2
ileum 1
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 5 99.16 Very High Very High Very High
dorsal root ganglion 42 94.16 High High
Potency 8 89.04 High High
tetrodotoxin 1 88.20 High High
antagonist 18 86.72 High High
Pain 6 76.48 Quite High
Opioid 4 75.00 Quite High
substance P 4 73.80 Quite High
agonist 12 69.84 Quite High
Inflammation 17 46.24 Quite Low
Disease Link Frequency Relevance Heat
Fever 329 99.52 Very High Very High Very High
Ganglion Cysts 44 94.16 High High
Pain 6 76.48 Quite High
Nervous System Injury 12 70.72 Quite High
Injury 2 61.28 Quite High
Diarrhoea 3 50.08 Quite High
Cv General 2 Under Development 4 47.08 Quite Low
INFLAMMATION 21 46.24 Quite Low
Stress 2 40.24 Quite Low
Cv General 3 Under Development 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EP3 receptors mediate the potentiating effect of PGE2
EP3 Binding (receptors) of
1) Confidence 0.17 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0.17
For example, the EP3D receptor is known to couple to Gi or Gq to reduce cAMP level in cells [45].
EP3D receptor Binding (couple) of
2) Confidence 0.16 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.61 Pain Relevance 0.37
The activity resides in the 11R,16S isomer, thus implying a stereospecific interaction at PGE receptors.
PGE Binding (interaction) of
3) Confidence 0.10 Published 1993 Journal Prostaglandins Section Abstract Doc Link 8234830 Disease Relevance 0.05 Pain Relevance 0.09
However, the relative potencies of binding to mu-receptor in [Gln8]- and [Tyr31]-analogs were found to be consistent with those of analgesic and guinea pig ileum assays, whereas the binding to beta-EP receptor of all analogs appeared to be related to the charge properties of beta-EP molecule.
beta-EP receptor Spec (appeared) Binding (binding) of in ileum associated with analgesic
4) Confidence 0.02 Published 1988 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2851563 Disease Relevance 0 Pain Relevance 0.71
Indeed, E-series prostaglandins (PGEs) are involved in the endogenous fever mechanism, and prostaglandin E2 (PGE2) in particular is acknowledged as the primary mediator of fever induction20 through an interaction with the EP3 receptor.25,26 However, there is no evidence that prostaglandin E1 (PGE1), of which misoprostol is an analogue, acts differently from PGE2:20,27 in fact, the biologically active form of misoprostol, misoprostol acid, has been shown to bind to the EP3 receptor.28 Considering this evidence, we theorise that in the fever cases presented, misoprostol may be mimicking endogenous PGEs in the thermoregulatory pathway by shifting the hypothalamic set point upwards and stimulating temperature elevation.
EP3 receptor Binding (interaction) of in PGE2 associated with fever
5) Confidence 0.01 Published 2010 Journal Bjog Section Body Doc Link PMC2878599 Disease Relevance 1.08 Pain Relevance 0
Indeed, E-series prostaglandins (PGEs) are involved in the endogenous fever mechanism, and prostaglandin E2 (PGE2) in particular is acknowledged as the primary mediator of fever induction20 through an interaction with the EP3 receptor.25,26 However, there is no evidence that prostaglandin E1 (PGE1), of which misoprostol is an analogue, acts differently from PGE2:20,27 in fact, the biologically active form of misoprostol, misoprostol acid, has been shown to bind to the EP3 receptor.28 Considering this evidence, we theorise that in the fever cases presented, misoprostol may be mimicking endogenous PGEs in the thermoregulatory pathway by shifting the hypothalamic set point upwards and stimulating temperature elevation.
EP3 receptor Binding (bind) of in PGE2 associated with fever
6) Confidence 0.01 Published 2010 Journal Bjog Section Body Doc Link PMC2878599 Disease Relevance 1.05 Pain Relevance 0
The latter, negative results can be explained, at least partially, as due to self-aggregation of PGE in aqueous solutions and the subsequent loss of biological activity.
PGE Binding (aggregation) of
7) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.52 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox