INT299981

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.08
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (FTSJ3) nucleolus (FTSJ3) nucleus (FTSJ3)
Anatomy Link Frequency
OECs 1
thickening 1
FTSJ3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 98.60 Very High Very High Very High
Bioavailability 10 97.96 Very High Very High Very High
Inflammation 51 97.04 Very High Very High Very High
ischemia 20 87.72 High High
alcohol 3 62.20 Quite High
antagonist 5 51.36 Quite High
imagery 3 44.32 Quite Low
depression 5 23.92 Low Low
Angina 13 21.44 Low Low
Nicotine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 5 99.44 Very High Very High Very High
Diabetes Mellitus 31 97.96 Very High Very High Very High
INFLAMMATION 51 97.04 Very High Very High Very High
Pathologic Constriction 20 91.28 High High
Cv Unclassified Under Development 30 87.72 High High
Coronary Artery Disease 135 87.44 High High
Disease 21 87.16 High High
Myocardial Infarction 118 83.92 Quite High
Stress 25 83.32 Quite High
Neointima 15 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oestrogens augment production and survival of EPCs, thereby increasing the circulating levels of these cells [82].
Gene_expression (production) of EPCs
1) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.31 Pain Relevance 0.30
For example, rosiglitazone was shown to attenuate the negative effects of C-reactive protein on EPCs and enhance NO-production of EPCs [78].
Gene_expression (production) of EPCs
2) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.30 Pain Relevance 0.32
Transplantation of EPCs
Gene_expression (Transplantation) of EPCs
3) Confidence 0.07 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.86 Pain Relevance 0
This hypothesis has been challenged by animal studies, which reveal that transfusion of EPCs led to reduced intimal thickening of the injured arterial wall, as a result of accelerated reendothelialization [57].
Gene_expression (transfusion) of EPCs in thickening
4) Confidence 0.07 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.68 Pain Relevance 0
Hyperglycemia significantly reduces eNOS production by EPCs with a corresponding decline in nitric oxide (NO) bioavailability [31].
Gene_expression (production) of EPCs associated with hyperglycemia and bioavailability
5) Confidence 0.07 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.58 Pain Relevance 0.05
Many highly expressed transcripts in eEPCs are haematopoietic specific (RUNX1, WAS, LYN) with links to immunity and inflammation (TLRs, CD14, HLAs), whereas many transcripts involved in vascular development and angiogenesis-related signalling pathways (Tie2, eNOS, Ephrins) are highly expressed in OECs.
Gene_expression (expressed) of eEPCs in OECs associated with inflammation
6) Confidence 0.01 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC2881111 Disease Relevance 0.10 Pain Relevance 0.05
Respective immunophenotypes using flow cytometry demonstrated eEPCs express haematopoietic markers CD45 and CD14, while OECs express endothelial markers CD146 and CD105 (R.
Gene_expression (express) of eEPCs
7) Confidence 0.01 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.11 Pain Relevance 0.03
Lists of the top 20 differentially expressed transcripts in eEPCs/OECs are shown in Table 1 and 2, respectively.
Gene_expression (expressed) of eEPCs
8) Confidence 0.00 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.14 Pain Relevance 0

General Comments

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