INT299989

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PRKCA, IL8) nucleoplasm (PRKCA) mitochondrion (PRKCA)
small molecule metabolic process (PRKCA) endoplasmic reticulum (PRKCA) intracellular (IL8)
Anatomy Link Frequency
fibroblasts 2
PRKCA (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 50 100.00 Very High Very High Very High
Kinase C 3 100.00 Very High Very High Very High
Inflammation 18 80.48 Quite High
Pain 30 77.68 Quite High
b2 receptor 11 76.32 Quite High
cytokine 5 56.48 Quite High
Eae 14 52.40 Quite High
Acute pain 1 50.00 Quite Low
B1 receptor 17 28.92 Quite Low
nociceptor 4 24.56 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 19 80.48 Quite High
Pain 32 77.68 Quite High
Inflammatory Pain 13 52.40 Quite High
Injury 32 51.72 Quite High
Nociception 2 34.80 Quite Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase C (PKC) signaling pathway seems to be responsible for BK induced IL-8 production in gingival fibroblasts [40], and PI-PLC and NF-?
PKC Positive_regulation (responsible) of Gene_expression (production) of IL-8 in fibroblasts associated with kinase c and bradykinin
1) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.45 Pain Relevance 0.67

General Comments

This test has worked.

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