INT30

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 158
Total Number 164
Disease Relevance 99.00
Pain Relevance 41.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
plasma 16
G cells 5
blood 4
neurons 3
spinal 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 114 100.00 Very High Very High Very High
Somatostatin 106 100.00 Very High Very High Very High
peptic ulcer disease 69 100.00 Very High Very High Very High
Chronic pancreatitis 56 100.00 Very High Very High Very High
Enkephalin 40 100.00 Very High Very High Very High
Serotonin 17 100.00 Very High Very High Very High
qutenza 59 99.98 Very High Very High Very High
narcan 8 99.84 Very High Very High Very High
Pain 116 99.80 Very High Very High Very High
abdominal pain 65 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 366 100.00 Very High Very High Very High
Disease 355 100.00 Very High Very High Very High
Ulcers 239 100.00 Very High Very High Very High
Pancreatitis 94 100.00 Very High Very High Very High
Cancer 220 99.98 Very High Very High Very High
Cystadenocarcinoma 12 99.96 Very High Very High Very High
Pain 134 99.80 Very High Very High Very High
Pharyngitis 48 99.74 Very High Very High Very High
Duodenal Ulcer 91 99.72 Very High Very High Very High
Colon Diverticulum 84 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to synthesize gastrin analogues and test them for their ability to inhibit gastrin-stimulated acid secretion.
Gene_expression (synthesize) of gastrin
1) Confidence 0.78 Published 1989 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2762757 Disease Relevance 0.19 Pain Relevance 0.14
The results indicate that diseases with increased synthesis of gastrin are accompanied by an abnormal degree of sulfation.
Gene_expression (synthesis) of gastrin associated with disease
2) Confidence 0.76 Published 1983 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 6669933 Disease Relevance 0.97 Pain Relevance 0.07
At least six enteroendocrine cell types are present in the gut of B. conchonius: 1. a cell type (I) with small secretory granules, present throughout the intestine, and possibly involved in the regulation of gut motility; 2. a C-terminal gastrin immunoreactive cell, probably producing a caerulein-like peptide; these cells are located at the upper parts of the folds, especially in the proximal part of the intestinal bulb; 3. a met-enkephalin-immunoreactive cell, present throughout the first segment; 4. a glucagon-immunoreactive cell, which is rare in the first segment; 5. a PP-immunoreactive cell, mainly present in the first half of the first segment; 6. an immunoreactive cell, which cannot at present be specified, located in the intestinal bulb.
Gene_expression (producing) of gastrin in gut associated with enkephalin
3) Confidence 0.76 Published 1982 Journal Cell Tissue Res. Section Abstract Doc Link 6758947 Disease Relevance 0 Pain Relevance 0.13
Serum gastrin levels in children with peptic ulcer disease.
Gene_expression (levels) of gastrin associated with peptic ulcer disease and disease
4) Confidence 0.76 Published 1992 Journal J. Formos. Med. Assoc. Section Title Doc Link 1354689 Disease Relevance 0.91 Pain Relevance 0.35
Angiographic findings in one giant cell carcinoma, one cystadenocarcinoma, one poorly vascularized mucinous cystadenocarcinoma, as well as in two avascular (gastrin- and glucagon-producing) islet-cell tumors of the pancreas are described.
Gene_expression (producing) of gastrin in pancreas associated with mucinous cystadenocarcinoma, cancer, cystadenocarcinoma and giant cell carcinoma
5) Confidence 0.76 Published 1976 Journal Rofo Section Abstract Doc Link 188740 Disease Relevance 1.20 Pain Relevance 0.09
Post-prandial serum gastrin concentrations, expressed as per cent increase, were higher in heavy drinkers (No. 14) and statistically significant at 120 minutes (40.57% vs 9.58%, p less than 0.025); as well as in smoker patients (No. 31), at 15, 30 and 60 minutes (227.59% vs 123.52%, 177.23% vs 101.62%, 0.025 and p less than 0.05).
Gene_expression (expressed) of gastrin
6) Confidence 0.76 Published 1989 Journal Minerva Med. Section Abstract Doc Link 2747982 Disease Relevance 0.53 Pain Relevance 0.11
The gastrin levels were expressed in absolute values and as per cent increase of fasting serum gastrin concentrations.
Gene_expression (expressed) of gastrin
7) Confidence 0.76 Published 1989 Journal Minerva Med. Section Abstract Doc Link 2747982 Disease Relevance 0.63 Pain Relevance 0.13
This review highlights some recent advances in the field by outlining gastrin biosynthesis, summarizing current understanding of gastrin receptors, describing the regulation of gastrin release, and discussing the clinical implications of gastrin in the pathogenesis of peptic ulcer disease.
Gene_expression (biosynthesis) of gastrin associated with peptic ulcer disease and disease
8) Confidence 0.76 Published 1997 Journal Annu. Rev. Physiol. Section Abstract Doc Link 9074765 Disease Relevance 0.30 Pain Relevance 0.15
It was also discovered that pentagastrin, MAF and enkephalins produce a different action on metabolism of biogenic amines.
Gene_expression (produce) of gastrin associated with enkephalin
9) Confidence 0.75 Published 1981 Journal Biull Eksp Biol Med Section Abstract Doc Link 6266552 Disease Relevance 0 Pain Relevance 0.88
Chronic alcoholism, however, does not appear to be the only factor responsible for the increased plasma gastrin levels in these patients.


Gene_expression (levels) of gastrin in plasma
10) Confidence 0.75 Published 2001 Journal Ann Saudi Med Section Body Doc Link 17264580 Disease Relevance 0.14 Pain Relevance 0
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Gene_expression (expression) of gastrin associated with qutenza and somatostatin
11) Confidence 0.67 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.72
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Gene_expression (expression) of gastrin associated with qutenza and somatostatin
12) Confidence 0.67 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.71
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Gene_expression (expression) of gastrin associated with qutenza and somatostatin
13) Confidence 0.67 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.72
After a single dose of 100 mg/kg in fasting rats, ebrotidine increased significantly serum gastrin levels within 2 and 5 h after administration, but 8 h after administration serum gastrin levels returned to normal values.
Gene_expression (levels) of gastrin
14) Confidence 0.67 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.15
The increase in somatostatin secretion caused by DMPP and field stimulation, as well as the resistance of gastrin and somatostatin secretion to atropine, was consistent with preferential activation of noncholinergic neurons at the stimulatory modalities used.
Gene_expression (resistance) of gastrin in neurons associated with somatostatin
15) Confidence 0.66 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.46
Eight patients with chronic duodenal ulcer and referred for proximal gastric vagotomy were studied. 24-hour intragastric acidity and plasma gastrin levels were investigated in the same patients on three consecutive occasions: preentry without any treatment; after 4 weeks of administration of 20 mg of omeprazole daily, and 4-6 months after proximal gastric vagotomy.
Gene_expression (levels) of gastrin in proximal associated with duodenal ulcer
16) Confidence 0.66 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2227275 Disease Relevance 0.36 Pain Relevance 0.09
Post-stimulation gastrin concentration were higher in chronic pancreatitis patients or in normal alcoholics (peak post-stimulation value: 74 +/- 41 and 74 +/- 43 pg/ml respectively) than in cirrhotics or non alcoholic controls (45 +/- 26 and 41 +/- 15 pg/ml respectively) (m +/- SD).
Gene_expression (concentration) of gastrin associated with chronic pancreatitis
17) Confidence 0.66 Published 1980 Journal Horm. Metab. Res. Section Abstract Doc Link 7409735 Disease Relevance 0.44 Pain Relevance 0.15
Plasma gastrin levels were measured by radioimmunoassay before and after a test meal associated with 40 ml ethanol in 21 patients presenting with chronic calcifying pancreatitis, in 10 apparently normal subjects drinking since at least 5 years 100 g alcohol a day, in 14 subjects presenting hepatic alcoholic cirrhosis and in 18 apparently normal non alcoholic controls.
Gene_expression (levels) of gastrin in Plasma associated with pancreatitis, alcoholic liver cirrhosis and alcohol
18) Confidence 0.66 Published 1980 Journal Horm. Metab. Res. Section Abstract Doc Link 7409735 Disease Relevance 0.40 Pain Relevance 0.11
Both treatments resulted in a modest increase in plasma levels of gastrin that were far below the gastrin levels observed in achlorhydric patients, e.g., patients with pernicious anemia.
Gene_expression (levels) of gastrin in plasma associated with pernicious anemia
19) Confidence 0.66 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2227275 Disease Relevance 0.23 Pain Relevance 0
It is concluded that PG given orally in capsules is a potent inhibitor of gastric acid and serum gastrin response to a meal and that this effect may be of potential value in the treatment of peptic ulcer disease.
Gene_expression (response) of gastrin in capsules associated with peptic ulcer disease and disease
20) Confidence 0.66 Published 1979 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 395627 Disease Relevance 0.32 Pain Relevance 0.10

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