INT300004

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.77
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle cells 2
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
b2 receptor 127 100.00 Very High Very High Very High
Nicotine 384 99.98 Very High Very High Very High
Analgesic 2 98.44 Very High Very High Very High
bradykinin 214 98.28 Very High Very High Very High
dexamethasone 44 98.08 Very High Very High Very High
Inflammation 110 97.80 Very High Very High Very High
cytokine 17 97.28 Very High Very High Very High
Spinal cord 4 91.16 High High
agonist 48 82.56 Quite High
B1 receptor 45 79.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 111 97.80 Very High Very High Very High
Asthma 60 66.96 Quite High
Pain 32 63.68 Quite High
Injury 36 62.44 Quite High
Targeted Disruption 1 60.00 Quite High
Nociception 2 55.76 Quite High
Inflammatory Pain 13 42.92 Quite Low
Pressure And Volume Under Development 8 27.12 Quite Low
Nicotine Addiction 48 5.00 Very Low Very Low Very Low
Pulmonary Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In experimental studies, the expression of B1 receptors has been reported to occur in response to the B1 ligand Lys-des-Arg9-BK [12] and inflammatory cytokines such as IL-1?
Positive_regulation (occur) of Gene_expression (expression) of B1 associated with inflammation, bradykinin and cytokine
1) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.49 Pain Relevance 1.07
The increase in B1 and B2 receptor mRNA and protein expression after organ culture with nicotine strengthens the evidence for an alteration at the receptor level rather than a down-stream process.
Positive_regulation (increase) of Gene_expression (expression) of B1 associated with nicotine and b2 receptor
2) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.19 Pain Relevance 0.43
Pharmacological inhibition of JNK abolished the nicotine-enhanced kinin B1 and B2 receptor-mediated contractions (Fig. 7A-B) and decreased the nicotine-enhanced kinin B1 and B2 receptor mRNA expressions (Fig. 4B).


Positive_regulation (enhanced) of Gene_expression (expressions) of B1 associated with nicotine and b2 receptor
3) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.09 Pain Relevance 0.76
An increase in kinin B1 (Fig. 5A-B) and B2 (Fig. 5C-D) receptor protein expressions were seen in both the airway epithelial and smooth muscle cells (Fig. 5E-F).
Positive_regulation (increase) of Gene_expression (expressions) of B1 in smooth muscle cells
4) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.41
Effects of nicotine on airway kinin B1 and B2 receptor mRNA and protein expressions
Positive_regulation (airway) of Gene_expression (expressions) of B1 associated with nicotine and b2 receptor
5) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.44

General Comments

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