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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle 2
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 91 96.24 Very High Very High Very High
Kinase C 4 96.16 Very High Very High Very High
Inflammation 41 85.24 High High
Nicotine 96 83.36 Quite High
b2 receptor 40 81.08 Quite High
Pain 30 66.24 Quite High
agonist 15 50.00 Quite Low
Acute pain 1 50.00 Quite Low
cytokine 8 45.04 Quite Low
Eae 14 40.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 85.24 High High
Nicotine Addiction 12 84.24 Quite High
Asthma 15 77.88 Quite High
Hypersensitivity 2 72.60 Quite High
Pain 32 66.24 Quite High
Injury 33 56.48 Quite High
Pressure And Volume Under Development 2 50.96 Quite High
Inflammatory Pain 13 40.96 Quite Low
Nociception 2 39.56 Quite Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several other studies showed an induction of IL-6, IL-8 and CCL2 via activation of B1 or B2 receptors in a variety of cells [41-47].
Positive_regulation (induction) of Positive_regulation (activation) of B1
1) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.39 Pain Relevance 0.63
Stimulation of kinin B1 and B2 receptors on the airway smooth muscle directly activates the inositol 1,4,5-trisphosphate (IP3) pathway increasing intracellular Ca2+ levels which subsequently activates the cellular contractile machinery [18].
Positive_regulation (activates) of Positive_regulation (Stimulation) of B1 in smooth muscle
2) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.43 Pain Relevance 0.50

General Comments

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