INT30001

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.31
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 12
blood 2
leukocyte 2
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 212 99.84 Very High Very High Very High
Migraine 14 99.50 Very High Very High Very High
depression 73 97.04 Very High Very High Very High
Angina 3 96.16 Very High Very High Very High
Bioavailability 2 85.04 High High
agonist 8 83.92 Quite High
Inflammation 18 68.72 Quite High
cva 8 61.88 Quite High
Hippocampus 43 32.44 Quite Low
COX-2 inhibitor 2 26.64 Quite Low
Disease Link Frequency Relevance Heat
Headache 10 99.50 Very High Very High Very High
Depression 95 97.04 Very High Very High Very High
Cv General 3 Under Development 11 96.16 Very High Very High Very High
Diabetes Mellitus 35 94.04 High High
Suicidal Behaviour 123 93.68 High High
Nicotine Addiction 3 93.60 High High
INFLAMMATION 24 89.08 High High
Acute Coronary Syndrome 8 88.96 High High
Cardiovascular Disease 11 79.68 Quite High
Migraine With Aura 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a non-linear relationship between inhibition of platelet TXA2 generation and inhibition of TXA2-dependent platelet aggregation.
Negative_regulation (inhibition) of Gene_expression (generation) of platelet in platelet
1) Confidence 0.57 Published 2004 Journal Thromb J Section Body Doc Link PMC331420 Disease Relevance 0.12 Pain Relevance 0.41
Nowadays, blockade of the most important and highly expressed platelet receptor, the fibrinogen-binding integrin receptor GPIIb/IIIa (or ???
Negative_regulation (blockade) of Gene_expression (expressed) of platelet in platelet
2) Confidence 0.57 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.41 Pain Relevance 0.08
Furthermore, aspirin failure may be due to enhanced formation of vasoactive and/or proaggregatory eicosanoids despite an almost complete suppression of platelet TXA2 biosynthesis by aspirin.
Negative_regulation (suppression) of Gene_expression (biosynthesis) of platelet in platelet associated with aspirin
3) Confidence 0.42 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592549 Disease Relevance 0.26 Pain Relevance 0.46
However, when BDNF level was determined in platelets, it was found that platelet BDNF levels were lower in both nonsuicidal and suicidal depressed patients compared with healthy controls, whereas no significant differences were noted between nonsuicidal and suicidal depressed patients.188 Interestingly, Dawood et al189 used direct internal jugular vein blood sampling methods to circumvent the issue of whether BDNF is released from other sources than the brain and they examined the relationship between brain BDNF production and suicide risk in untreated patients with depression.
Negative_regulation (lower) of Gene_expression (levels) of platelet in blood associated with suicidal behaviour and depression
4) Confidence 0.42 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.19 Pain Relevance 0.14
These data do not confirm a general platelet malfunction in migraine patients, but suggest a decreased functional capacity of platelet beta-adrenoceptors and an altered metabolism of prostacyclin and LDL-cholesterol.
Negative_regulation (metabolism) of Gene_expression (capacity) of platelet in platelet associated with migraine
5) Confidence 0.41 Published 1988 Journal Acta Neurol. Scand. Section Abstract Doc Link 2851913 Disease Relevance 0.62 Pain Relevance 0.59
These data do not confirm a general platelet malfunction in migraine patients, but suggest a decreased functional capacity of platelet beta-adrenoceptors and an altered metabolism of prostacyclin and LDL-cholesterol.
Negative_regulation (decreased) of Gene_expression (capacity) of platelet in platelet associated with migraine
6) Confidence 0.41 Published 1988 Journal Acta Neurol. Scand. Section Abstract Doc Link 2851913 Disease Relevance 0.62 Pain Relevance 0.59
We assessed prostanoid metabolite excretion (PGE-M, TXB(2), 6-keto-PGF(1alpha), 11-dehydro-TXB(2), 2,3-dinor-TXB(2), and dinor-6-keto-PGF(1alpha)), the expression of platelet activation markers (CD62P, PAC-1, fibrinogen), platelet-leukocyte formation, the endogenous thrombin potential, platelet cAMP content and plasma thrombomodulin level.
Negative_regulation (assessed) of Gene_expression (expression) of platelet in leukocyte
7) Confidence 0.41 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0
Among these drugs picotamide attracted the attention of researchers for its ability to inhibit both TxA2 platelet synthase and platelet TxA2 receptors and, in turn, platelet aggregation.
Negative_regulation (inhibit) of Gene_expression (synthase) of platelet in platelet
8) Confidence 0.41 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.08 Pain Relevance 0.20

General Comments

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