INT30002

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Context Info
Confidence 0.42
First Reported 1983
Last Reported 1988
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 6
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 10 100.00 Very High Very High Very High
Migraine 7 99.50 Very High Very High Very High
cINOD 2 80.64 Quite High
cva 1 61.88 Quite High
Potency 1 35.72 Quite Low
Disease Link Frequency Relevance Heat
Headache 5 99.50 Very High Very High Very High
INFLAMMATION 2 80.44 Quite High
Migraine With Aura 2 75.00 Quite High
Cv General 3 Under Development 1 61.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data do not confirm a general platelet malfunction in migraine patients, but suggest a decreased functional capacity of platelet beta-adrenoceptors and an altered metabolism of prostacyclin and LDL-cholesterol.
Negative_regulation (decreased) of Negative_regulation (capacity) of platelet in platelet associated with migraine
1) Confidence 0.42 Published 1988 Journal Acta Neurol. Scand. Section Abstract Doc Link 2851913 Disease Relevance 0.62 Pain Relevance 0.59
Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities.
Negative_regulation (prevent) of Negative_regulation (effect) of platelet in platelet associated with aspirin
2) Confidence 0.42 Published 1983 Journal Biochim. Biophys. Acta Section Title Doc Link 6411131 Disease Relevance 0.08 Pain Relevance 0.18
Structural requirements for preventing the aspirin- and the arachidonate-induced inactivation of platelet cyclo-oxygenase: additional evidence for distinct enzymatic sites.
Negative_regulation (preventing) of Negative_regulation (inactivation) of platelet in platelet associated with aspirin
3) Confidence 0.42 Published 1984 Journal Eur. J. Pharmacol. Section Title Doc Link 6423393 Disease Relevance 0.05 Pain Relevance 0.35

General Comments

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