INT300090

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 11.36
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PIAS3) enzyme binding (PIAS3) ligase activity (PIAS3)
cytoplasm (PIAS3)
Anatomy Link Frequency
T cells 2
plasma 1
PIAS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 100.00 Very High Very High Very High
Opioid 36 6.96 Low Low
drug abuse 18 5.00 Very Low Very Low Very Low
opiate 6 5.00 Very Low Very Low Very Low
Morphine 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 702 99.80 Very High Very High Very High
Infection 384 99.74 Very High Very High Very High
Opiate Addiction 474 99.48 Very High Very High Very High
Hepatitis 12 50.08 Quite High
Viral Infection 12 49.24 Quite Low
Disease 18 10.40 Low Low
Drug Dependence 18 5.00 Very Low Very Low Very Low
Liver Disease 12 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation was further confirmed by the correlation analyses, showing that there was a positive association between the levels of PIAS-3 and HCV viral loads (Fig. 8).
Gene_expression (levels) of PIAS-3 associated with hepatitis c virus infection
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.71 Pain Relevance 0
We found that although heroin use or heroin use plus HCV infection had little effects on the expression of PIAS-1, PIAS-x and PIAS-y in CD56+ T cells, the levels of PIAS-3 gene expression in CD56+ T cells from the HCV-infected heroin users was significantly increased, comparing with the control subjects (Fig. 7).
Gene_expression (expression) of PIAS-3 gene in T cells associated with hepatitis c virus infection, opiate addiction and infection
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.54 Pain Relevance 0
by CD56+ T cells and the levels of HCV RNA in plasma, or between the levels of SOCS-3/PIAS-3 in CD56+ T cells and the levels of HCV RNA in plasma was performed using Spearman's rank test (Prism 4.0 software).
Gene_expression (levels) of PIAS-3 in plasma associated with hepatitis c virus infection
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 0.38 Pain Relevance 0
In addition, there was no significant difference in the expression of SOCS-3 and PIAS-3 between the heroin users without HCV infection and the heroin users with HCV infection (Fig. 7).
Gene_expression (expression) of PIAS-3 associated with hepatitis c virus infection, opiate addiction and infection
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.97 Pain Relevance 0.04
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Gene_expression (expression) of PIAS-3 associated with hepatitis c virus infection, opiate addiction, infection and cytokine
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 2.13 Pain Relevance 0.05
Although there was an increase in PIAS-3 levels in CD56+ T cells from the heroin users without HCV infection, this difference was not statistically significant (Fig. 7).
Gene_expression (levels) of PIAS-3 in T cells associated with hepatitis c virus infection, opiate addiction and infection
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.63 Pain Relevance 0.04

General Comments

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