INT300096

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PIAS3) enzyme binding (PIAS3) ligase activity (PIAS3)
cytoplasm (PIAS3)
PIAS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 99.16 Very High Very High Very High
Opioid 12 37.60 Quite Low
drug abuse 6 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 128 99.30 Very High Very High Very High
Hepatitis C Virus Infection 234 99.10 Very High Very High Very High
Opiate Addiction 158 98.92 Very High Very High Very High
Hepatitis 4 46.96 Quite Low
Viral Infection 4 46.12 Quite Low
Disease 6 41.04 Quite Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Liver Disease 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Negative_regulation (inhibitors) of PIAS-3 associated with hepatitis c virus infection, opiate addiction, infection and cytokine
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 1.88 Pain Relevance 0.05
Taken together, the findings presented in this study provide compelling ex vivo as well as in vivo evidence that heroin use or heroin use plus HCV infection, through the induction of two key suppressors (SOCS-3 and PIAS-3) in IL-12 pathway, suppressed IFN-?
Negative_regulation (suppressors) of PIAS-3 associated with hepatitis c virus infection, opiate addiction and infection
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.74 Pain Relevance 0

General Comments

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