INT300099

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 4.23
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PIAS3) enzyme binding (PIAS3) ligase activity (PIAS3)
cytoplasm (PIAS3)
Anatomy Link Frequency
T cells 4
PIAS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 83.44 Quite High
Opioid 12 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 234 100.00 Very High Very High Very High
Opiate Addiction 158 100.00 Very High Very High Very High
Infection 128 98.02 Very High Very High Very High
Disease 6 5.00 Very Low Very Low Very Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Liver Disease 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
Viral Infection 4 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that although heroin use or heroin use plus HCV infection had little effects on the expression of PIAS-1, PIAS-x and PIAS-y in CD56+ T cells, the levels of PIAS-3 gene expression in CD56+ T cells from the HCV-infected heroin users was significantly increased, comparing with the control subjects (Fig. 7).
Positive_regulation (increased) of Gene_expression (expression) of PIAS-3 gene in T cells associated with hepatitis c virus infection, opiate addiction and infection
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.59 Pain Relevance 0
Although there was an increase in PIAS-3 levels in CD56+ T cells from the heroin users without HCV infection, this difference was not statistically significant (Fig. 7).
Positive_regulation (increase) of Gene_expression (levels) of PIAS-3 in T cells associated with hepatitis c virus infection, opiate addiction and infection
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.64 Pain Relevance 0.04

General Comments

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