INT300100

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 8.51
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PIAS3) enzyme binding (PIAS3) ligase activity (PIAS3)
cytoplasm (PIAS3)
Anatomy Link Frequency
T cells 2
PIAS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 86.88 High High
Opioid 24 37.60 Quite Low
drug abuse 12 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
Morphine 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
opioid receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 256 99.72 Very High Very High Very High
Hepatitis C Virus Infection 468 99.52 Very High Very High Very High
Opiate Addiction 316 99.48 Very High Very High Very High
Viral Infection 8 91.88 High High
Hepatitis 8 90.76 High High
Disease 12 41.04 Quite Low
Drug Dependence 12 5.00 Very Low Very Low Very Low
Liver Disease 8 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CD56+ T cells freshly isolated from the HCV-infected heroin users had significantly higher levels of PIAS-3 than those from the healthy subjects (Fig. 7).
Positive_regulation (levels) of PIAS-3 in T cells associated with opiate addiction and hepatitis c virus infection
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.54 Pain Relevance 0.04
Taken together, the findings presented in this study provide compelling ex vivo as well as in vivo evidence that heroin use or heroin use plus HCV infection, through the induction of two key suppressors (SOCS-3 and PIAS-3) in IL-12 pathway, suppressed IFN-?
Positive_regulation (induction) of PIAS-3 associated with hepatitis c virus infection, opiate addiction and infection
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.76 Pain Relevance 0
Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users

Background

Positive_regulation (Upregulation) of PIAS-3 associated with opiate addiction and hepatitis c virus infection
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2834757 Disease Relevance 1.58 Pain Relevance 0
Although there was an increase in PIAS-3 levels in CD56+ T cells from the heroin users without HCV infection, this difference was not statistically significant (Fig. 7).
Positive_regulation (increase) of PIAS-3 in T cells associated with hepatitis c virus infection, opiate addiction and infection
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.63 Pain Relevance 0.04

General Comments

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