INT300107

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 3.58
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOCS3) aging (SOCS3) cytoplasm (SOCS3)
Anatomy Link Frequency
T cells 2
SOCS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Opioid 12 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 128 99.98 Very High Very High Very High
Hepatitis C Virus Infection 234 99.78 Very High Very High Very High
Opiate Addiction 158 99.60 Very High Very High Very High
Hepatitis 4 50.56 Quite High
Viral Infection 4 49.72 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Liver Disease 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the suppressor family members examined, the level of SOCS-3 gene expression was elevated in CD56+ T cells isolated from the heroin users with or without HCV infection (Fig. 7).
Positive_regulation (elevated) of Gene_expression (expression) of SOCS-3 in T cells associated with hepatitis c virus infection, opiate addiction and infection
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.45 Pain Relevance 0
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Positive_regulation (induced) of Gene_expression (expression) of cytokine signaling protein-3 associated with hepatitis c virus infection, opiate addiction, infection and cytokine
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 2.13 Pain Relevance 0.05

General Comments

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