INT30011

Context Info Confidence 0.54 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 18 Total Number 18 Disease Relevance 4.65 Pain Relevance 3.54

extracellular space (Sepp1) growth (Sepp1) extracellular region (Sepp1)

Anatomy Link Frequency spines 3 hindlimbs 1 Sepp1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Ultiva 5 99.56 anesthesia 3 99.28 headache 78 98.82 Spinal cord 28 97.52 Triptan 15 96.40 Action potential 4 94.80 depression 62 92.96 cINOD 21 92.80 gABA 4 89.92 narcan 16 88.08

Disease Link Frequency Relevance Heat Heart Rate Under Development 2 99.90 Multiple Sclerosis 4 99.88 Headache 96 98.82 Anxiety Disorder 17 97.20 Injury 25 95.96 Depression 63 92.96 INFLAMMATION 3 91.36 Nociception 7 88.08 Cv Unclassified Under Development 4 87.56 Spinal Injuries 2 81.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While the SI-SEP and AI-AEP were minimally but significantly affected, fentanyl dose-dependently decreased the Vx-SEP and Vx-AEP.

Negative_regulation (decreased) of Vx-SEP

1) Confidence 0.54 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.26 Pain Relevance 0.07

The decrease of the Vx-SEP and Vx-AEP was parallelled by the dose-dependent decrease of the amount of CS-induced fear-conditioned behaviour.

Negative_regulation (decrease) of Vx-SEP associated with anxiety disorder

2) Confidence 0.54 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.26 Pain Relevance 0.07

However, SEP suppression by 50% occurred only at large (1.5 EC(50)) concentrations of propofol, and a measurable SEP was present in 8 of 18 rats, even at 10.8 EC(50).

Negative_regulation (suppression) of SEP

3) Confidence 0.38 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633560 Disease Relevance 0 Pain Relevance 0.46

Decreasing the amplitude of the SEP (downtraining) was associated with an increase in noxious sensitivity.

Negative_regulation (Decreasing) of SEP

4) Confidence 0.38 Published 1983 Journal Brain Res. Section Abstract Doc Link 6871694 Disease Relevance 0.23 Pain Relevance 0

These results suggest that the dose-dependent decrease of the Vx-SEP amplitude, rather than of the SI-SEP, indicates that the US was experienced as less unpleasant.

Negative_regulation (decrease) of Vx-SEP

5) Confidence 0.34 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.25 Pain Relevance 0.06

These results suggest that the dose-dependent decrease of the Vx-SEP amplitude, rather than of the SI-SEP, indicates that the US was experienced as less unpleasant.

Negative_regulation (decrease) of SI-SEP

6) Confidence 0.34 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.25 Pain Relevance 0.06

Patients with MOH had larger-amplitude block 1 SEPs than controls, and also lacked SEP habituation.

Negative_regulation (lacked) of SEP associated with headache

7) Confidence 0.30 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3024248 Disease Relevance 0.91 Pain Relevance 1.05

During EAE, the SEP decreased considerably and their onset was delayed.

Negative_regulation (decreased) of SEP associated with multiple sclerosis

8) Confidence 0.24 Published 2003 Journal Neuroreport Section Abstract Doc Link 12634475 Disease Relevance 0.29 Pain Relevance 0.15

When the first SEP component had decreased to 40-50% of control, the animals were retransfused to a MAP of 60-80 mmHg, to prevent further deterioration of SEP, and maintained at the new pressure level for the rest of the experiment.

Negative_regulation (decreased) of SEP

9) Confidence 0.22 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 2852436 Disease Relevance 0.62 Pain Relevance 0.61

This resulted in transient bradycardia and attenuated SEP.

Negative_regulation (attenuated) of SEP associated with heart rate under development

10) Confidence 0.22 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 2852436 Disease Relevance 0.63 Pain Relevance 0.61

There was an absence of SEP in surface recordings, indicating a loss of sensory function in the hindlimbs following transection injury.

Negative_regulation (absence) of SEP in hindlimbs associated with injury

11) Confidence 0.14 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.52 Pain Relevance 0.13

In corticosterone-treated cells the punctate synaptic SEP-GluR2 fluorescence started to decrease immediately on exposure to NMDA with a time course similar to the decrease in diffuse non-synaptic SEP-GluR2 (Figure 4B, D).

Negative_regulation (decrease) of SEP

12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.21 Pain Relevance 0.10

In direct contrast to control cells, the punctate and diffuse SEP-GluR2 in corticosterone-treated cells showed similar loss of SEP-GluR2 fluorescence kinetics upon NMDAR activation.

Negative_regulation (loss) of SEP

13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.08 Pain Relevance 0.04

Further, there was a much greater initial loss of SEP-GluR2 fluorescence from non-punctate regions.

Negative_regulation (loss) of SEP

14) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.14 Pain Relevance 0.07

PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased, and AKR1C2 and MKNK1 were increased in interstitial cystitis cases.

Negative_regulation (decreased) of SEPP1

15) Confidence 0.04 Published 2008 Journal J. Urol. Section Body Doc Link 18951569 Disease Relevance 0 Pain Relevance 0

Generally, spines exhibiting SEP-GluR1 loss had a lower spine-mito score and less mitochondrial association than those without loss.

Negative_regulation (loss) of SEP-GluR1 in spines

16) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC2853530 Disease Relevance 0 Pain Relevance 0

Both the spine-mito score and the percentage of spines associated with mitochondria showed a significant difference between bright spines that lost SEP-GluR1 signals and those exhibited no change under A?

Negative_regulation (lost) of SEP-GluR1 in spines

17) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC2853530 Disease Relevance 0 Pain Relevance 0

-O (<500 nM oligomers, based on the western blot) resulted in a marked loss of surface SEP-GluR1 at numerous spines (lower panels in Figure 1a, arrows; see also Figure S2 in Additional file 1), whereas similar exposure to a control saline (HBS) had no effect (upper panels in Figure 1a; see also Figure S2 in Additional file 1).

Negative_regulation (loss) of SEP-GluR1 in spines

18) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC2853530 Disease Relevance 0 Pain Relevance 0.06

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