INT300141

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.26 Pain Relevance 0.07

THADA (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 1 71.12 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 44 100.00 Disease 4 80.32 Ocular Toxicity (including Many Sub-types) 1 71.80 Cv General 3 Under Development 1 71.12 Renal Failure 1 70.80 Myocardial Infarction 2 70.20 Stroke 1 69.60 Obesity 6 56.76 Abdominal Obesity 1 55.44 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, substantial advances have been made in the past few years, with an increase in confirmed type 2 diabetes susceptibility loci from 3 genes (PPARG, KCNJ11, and TCF7L2) to almost 20 (with newly identified variants in the following genes: ADAMTS9, CDKAL1, CDKN2A/B, CAMK1D, FTO, HHEX/IDE, HNF1B, IGF2BP2, JAZF1, MTNR1B, NOTCH2, SLC30A8, THADA, TSPAN8, and WFS1) (14–17).

Positive_regulation (increase) of THADA associated with diabetes mellitus

1) Confidence 0.16 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 1.26 Pain Relevance 0.07

General Comments

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