INT300190

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8) plasma membrane (F8)
Anatomy Link Frequency
plasma 2
F8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 20 56.80 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 141 99.36 Very High Very High Very High
Hemorrhage 89 56.80 Quite High
Injury 15 26.20 Quite Low
Congenital Anomalies 3 22.24 Low Low
Hemarthrosis 14 21.28 Low Low
Anxiety Disorder 3 20.24 Low Low
Pressure And Volume Under Development 2 19.76 Low Low
Increased Venous Pressure Under Development 5 18.52 Low Low
Arthropathy 18 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Earlier cohort studies suggested an inverse relationship between the age at first exposure and the probability of inhibitor development.71,72 Later studies with multivariate analyses adjusted for other variables including family history of inhibitor development as well as FVIII gene mutation did not confirm these results.73,74 To the contrary, children starting prophylaxis before the age of three years experienced a 70% reduction in the risk of inhibitor development.73
Positive_regulation (as) of Gene_expression (mutation) of FVIII gene
1) Confidence 0.50 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835555 Disease Relevance 0.26 Pain Relevance 0.03
This was demonstrated in toxicology studies, which included injecting high doses of PEGLip-FVIII and PEGip-FVIIa into rats and rabbits (acute toxicology) and repeated injections (up to nine months of weekly injections) of PEGLip into rats and rabbits.45 PEGylated liposomes were also shown to be non-toxic in mice and dogs.62
Positive_regulation (injecting) of Gene_expression (doses) of PEGLip-FVIII
2) Confidence 0.46 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0.45 Pain Relevance 0
Similarly, ex-vivo rotational thrombelastometry experiments in whole blood drawn from hemophilic mice indicated that clotting times were much faster in mice injected with PEGLip-FVIII rather than with free FVIII.50 Such improvements in kinetics, clot firmness, and resistance to fibrinolysis depended on platelets as they were not observed when experiments were performed in platelet poor plasma.57
Positive_regulation (injected) of Gene_expression (with) of PEGLip-FVIII in plasma associated with coagulation disorder
3) Confidence 0.40 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox