INT30023

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Context Info
Confidence 0.17
First Reported 1988
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.84
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PAF1)
PAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 5 99.80 Very High Very High Very High
Catecholamine 1 98.32 Very High Very High Very High
tolerance 9 95.52 Very High Very High Very High
agonist 7 95.32 Very High Very High Very High
Neuropeptide 3 86.24 High High
Clonidine 4 84.56 Quite High
imagery 2 82.52 Quite High
Potency 2 77.44 Quite High
anesthesia 4 71.68 Quite High
antagonist 3 70.88 Quite High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 28 99.72 Very High Very High Very High
Arrhythmias 2 Under Development 51 98.68 Very High Very High Very High
Sepsis 2 93.08 High High
Cancer 2 92.68 High High
Heart Rate Under Development 24 87.60 High High
Death 162 77.16 Quite High
Myocardial Infarction 69 73.68 Quite High
Gastroesophageal Reflux Disease 6 72.40 Quite High
Emergencies 17 50.00 Quite Low
Stroke 3 43.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such tolerated noise in nonstationary data with known degrees of freedom does not significantly alter the mean PD2i values (Skinner et al 1994).
Neg (not) Regulation (alter) of PD2i
1) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621378 Disease Relevance 0.58 Pain Relevance 0.05
A positive correlation was found in the pD2- and pKA-values for noradrenaline (r = 0.976, P less than 0.05).
Regulation (values) of pD2 associated with noradrenaline
2) Confidence 0.16 Published 1988 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2852929 Disease Relevance 0 Pain Relevance 0.44
PD2 values (PD2 = -log(EC50)) for amplitude and slope were 6.4 +/- 0.7 and 6.0 +/- 0.3, respectively.
Regulation (values) of PD2
3) Confidence 0.03 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15085058 Disease Relevance 0 Pain Relevance 0.18
PD2 values (PD2 = -log(EC50)) for amplitude and slope were 6.4 +/- 0.7 and 6.0 +/- 0.3, respectively.
Regulation (values) of PD2
4) Confidence 0.03 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15085058 Disease Relevance 0 Pain Relevance 0.18
Examination by the NCA of the files that passed the randomized-phase surrogate test revealed only three cases that, when low-level noise was halved, had an effect on their PD2i test result.
Regulation (effect) of PD2i
5) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731023 Disease Relevance 0.61 Pain Relevance 0.03
For values of PD2i that lie in the transition zone between 1.6 and 1.4 (the cut-point, ROC area = 0.91)16 very small amounts of low-level noise can falsely increase low PD2i’s into this region; if data files had such transition zone PD2i scores, then a transition zone algorithm (TZA) was applied: if the mean PD2i was highly reduced from normal with >75% of the PD2i’s being below 3.0, then 0.2 degrees of freedom (dimension) was subtracted from each PD2i value.


Regulation (values) of PD2i
6) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731023 Disease Relevance 0.06 Pain Relevance 0.08
There was a strong positive correlation between the pD2 and pIC50 values for mammalian tachykinins and analogues (r = 0.907), but not for the non-mammalian tachykinins, which were all full agonists but variable binding competitors.
Neg (not) Regulation (values) of pD2 associated with agonist
7) Confidence 0.01 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9686947 Disease Relevance 0 Pain Relevance 0.43
Figure 2 shows accepted PD2i values for 7 Arrhythmia controls and 7 VF/VT subjects.
Regulation (values) of PD2i associated with arrhythmias 2 under development and arrhythmia under development
8) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504053 Disease Relevance 0.59 Pain Relevance 0

General Comments

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