INT300244

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
immune system 1
HLA-B (Homo sapiens)
HSR (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 96.02 Very High Very High Very High
Hypersensitivity 16 95.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 93.74 High High
Opportunistic Infections 1 75.56 Quite High
Fever 4 73.08 Quite High
Exanthema 8 72.72 Quite High
Adverse Drug Reaction 1 66.12 Quite High
Thrombosis 1 50.32 Quite High
Thrombocytopenia 1 36.64 Quite Low
Lymphopenia 1 35.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered or unusual drug metabolism and a susceptible immune system are believed to be important cofactors for the development of drug-related hypersensitivity.24 HIV-infected persons are likely to be at special risk of developing hypersensitivity reactions because of the disease associated perturbations in the immune system.25 Two members of a family who were treated with ABC both developed the HSR suggesting a genetic component to ABC HSR.26 Multiple studies have shown an association of the ABC HSR with HLA-B*5701.27–29 The use of this screening test to identify high risk patients has been shown by Rauch et al to reduce the occurrence of the ABC HSR.30 In this cohort involving more than 260 patients, the authors observed that the use of HLA-B*5701 screening decreased ABC HSR from 7% to <1%.
HLA-B Binding (association) of HSR in immune system associated with acquired immune deficiency syndrome or hiv infection, hypersensitivity and disease
1) Confidence 0.08 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.95 Pain Relevance 0

General Comments

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