INT30025

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 0.89
Pain Relevance 6.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
liver 9
L1210 2
brain 1
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 40 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
narcan 12 99.84 Very High Very High Very High
antagonist 8 99.34 Very High Very High Very High
opiate 18 99.10 Very High Very High Very High
opioid receptor 10 98.36 Very High Very High Very High
Intracerebroventricular 4 98.26 Very High Very High Very High
agonist 6 97.76 Very High Very High Very High
ischemia 6 93.08 High High
Somatostatin 6 88.24 High High
Disease Link Frequency Relevance Heat
Apoptosis 5 93.20 High High
Cv Unclassified Under Development 6 93.08 High High
Bordatella Infection 1 77.12 Quite High
Convulsion 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DFMO completely abolished elevation of ODC activity 6 h after reperfusion but did not change the percentage of fragmented DNA.
Negative_regulation (abolished) of Positive_regulation (elevation) of ODC
1) Confidence 0.59 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486179 Disease Relevance 0.81 Pain Relevance 0.35
Although the opiate antagonists naloxone and naltrexone totally blocked the effects of the opioid peptides on ODC induction, they also produced an inhibition of the asparagine-mediated increase in ODC activity.
Negative_regulation (inhibition) of Positive_regulation (increase) of ODC associated with antagonist, narcan, opiate and opioid
2) Confidence 0.59 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.45
L-365,260 prevented the activation of HDC but not of ODC in response to food intake and treatment with omeprazole, NaHCO3, or hypertonic NaCl.
Negative_regulation (prevented) of Positive_regulation (activation) of ODC
3) Confidence 0.58 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.14
Truncal vagotomy attenuated the increase of ODC activity in the intestinal mucosa and liver induced by 2-DG.
Negative_regulation (attenuated) of Positive_regulation (increase) of ODC in liver
4) Confidence 0.43 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782870 Disease Relevance 0 Pain Relevance 0.15
Although the opiate antagonists naloxone and naltrexone totally blocked the effects of the opioid peptides on ODC induction, they also produced an inhibition of the asparagine-mediated increase in ODC activity.
Negative_regulation (blocked) of Positive_regulation (induction) of ODC associated with antagonist, narcan, opiate and opioid
5) Confidence 0.43 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.45
In contrast, RC-160 suppressed omeprazole- and NaHCO3-evoked ODC activation but not that evoked by food intake or NaCl.
Negative_regulation (suppressed) of Positive_regulation (activation) of ODC
6) Confidence 0.43 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.18
In fact, a robust inhibition of both basal and induced liver ornithine decarboxylase activity was obtained in rat pups given 20 microg of morphine s.c.
Negative_regulation (inhibition) of Positive_regulation (induced) of ornithine decarboxylase in liver associated with morphine
7) Confidence 0.39 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.89
On the other hand, the increases in liver ODC were not prevented by naloxone, suggesting that these effects are not mediated through opioid-sensitive structures.
Negative_regulation (prevented) of Positive_regulation (increases) of ODC in liver associated with narcan and opioid
8) Confidence 0.39 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3559981 Disease Relevance 0 Pain Relevance 0.54
The inhibition of the induction of ODC activity was accompanied by a reduction of ODC mRNA level and an acceleration of ODC turnover.
Negative_regulation (inhibition) of Positive_regulation (induction) of ODC
9) Confidence 0.35 Published 1998 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9746211 Disease Relevance 0.08 Pain Relevance 0.44
Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.
Negative_regulation (decreased) of Positive_regulation (increases) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine
10) Confidence 0.34 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.53
Finally, as was the case for insulin induced stimulation of ornithine decarboxylase activity, i.c.v. injection of morphine markedly diminished insulin induced stimulation of hepatic ornithine decarboxylase mRNA accumulation.
Negative_regulation (diminished) of Positive_regulation (accumulation) of ornithine decarboxylase associated with morphine
11) Confidence 0.29 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 1.09
In difluoromethylornithine resistant L1210 cells stimulated to growth from quiescence, the selective kappa-opioidergic agonist trans-(+/-)-3,4-dichloro-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneaceta mid e (U-50488H) caused a dose dependent inhibition of the induction of ODC activity, with a half-maximal effect at about 1 microM.
Negative_regulation (inhibition) of Positive_regulation (induction) of ODC in L1210 associated with agonist
12) Confidence 0.18 Published 1996 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8664348 Disease Relevance 0 Pain Relevance 0.23
The (-)cis-(1S,2R)-U50488 stereoisomer, exhibiting low affinity for kappa and high affinity for sigma receptors and carbetapentane, another sigma ligand, also inhibited ODC induction, although less effectively than U-50488H.
Negative_regulation (inhibited) of Positive_regulation (induction) of ODC
13) Confidence 0.13 Published 1996 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8664348 Disease Relevance 0 Pain Relevance 0.38
Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.
Negative_regulation (decreased) of in brain Positive_regulation (increases) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine
14) Confidence 0.12 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.53

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