INT300258

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB6) mitochondrion (ABCB6) Golgi apparatus (ABCB6)
ATPase activity (ABCB6) plasma membrane (ABCB6) transmembrane transport (ABCB6)
ABCB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 4 92.16 High High
methadone 10 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 128 96.40 Very High Very High Very High
Disorders Of Creatine Metabolism 8 88.92 High High
Renal Insufficiency 2 77.44 Quite High
Cardiovascular Disease 20 61.00 Quite High
Myocardial Infarction 22 46.92 Quite Low
Chronic Renal Failure 10 39.24 Quite Low
Injury 2 28.24 Quite Low
Hypersensitivity 32 5.00 Very Low Very Low Very Low
Exanthema 16 5.00 Very Low Very Low Very Low
Vomiting 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It undergoes 3-step phosphorylation like ABC to form the active metabolite lamivudine triphosphate (3TC-TP) which competes with endogenous cytosine.
Phosphorylation (phosphorylation) of ABC
1) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.59 Pain Relevance 0
It should be pointed out that the phosphorylation pathways for 3TC and ABC are different.


Phosphorylation (phosphorylation) of ABC
2) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.43 Pain Relevance 0.05

General Comments

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