INT300260

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.10
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKR1A1) oxidoreductase activity (AKR1A1)
Anatomy Link Frequency
brain 1
AKR1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 26 100.00 Very High Very High Very High
headache 70 99.48 Very High Very High Very High
Pain 16 86.88 High High
Migraine 10 73.04 Quite High
methadone 5 67.04 Quite High
nud 1 44.60 Quite Low
analgesia 14 5.00 Very Low Very Low Very Low
acular 13 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 78 99.48 Very High Very High Very High
Hepatitis C Virus Infection 1 94.80 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 94.64 High High
Acidosis 7 91.16 High High
Pain 17 86.88 High High
Acid Base Imbalance 4 83.48 Quite High
Poisoning 11 82.40 Quite High
Photophobia 2 75.72 Quite High
Increased Venous Pressure Under Development 3 73.84 Quite High
Vomiting 10 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
He may also have co-ingested ethanol or other types of alcohols that are metabolized by alcohol dehydrogenase, such that the metabolism of methanol to formate was blocked.
Localization (metabolized) of alcohol dehydrogenase associated with alcohol
1) Confidence 0.10 Published 2010 Journal J Med Toxicol Section Body Doc Link PMC2861177 Disease Relevance 0.79 Pain Relevance 0.12
There have been concerns about possible pharmacokinetic interaction between ABC and ethanol, as both are metabolized by alcohol dehydrogenase.
Localization (metabolized) of alcohol dehydrogenase associated with alcohol
2) Confidence 0.08 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.41 Pain Relevance 0.22
Ethanol is metabolized into acetaldehyde by alcohol dehydrogenase, mainly in the liver, and then converted into acetate by mitochondrial aldehyde dehydrogenase in many tissues, including brain tissue [8], [9], [10].
Localization (metabolized) of alcohol dehydrogenase in brain associated with alcohol
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013144 Disease Relevance 1.90 Pain Relevance 1.84

General Comments

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