INT300284

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.51
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
cardiomyocyte 2
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 14 99.58 Very High Very High Very High
ketamine 1 55.12 Quite High
anesthesia 3 50.32 Quite High
Perioperative pain 1 39.44 Quite Low
Buprenorphine 1 37.12 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 12 99.58 Very High Very High Very High
Myocardial Infarction 78 99.12 Very High Very High Very High
Apoptosis 40 99.06 Very High Very High Very High
Hypertrophy 14 98.84 Very High Very High Very High
Diabetes Mellitus 55 92.48 High High
Coronary Heart Disease 10 82.80 Quite High
Hyperglycemia 2 42.08 Quite Low
Post Operative Pain 1 39.44 Quite Low
Stress 8 30.72 Quite Low
Obesity 1 25.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Regulation (changes) of Phosphorylation (phosphorylation) of p53 in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
1) Confidence 0.16 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.51 Pain Relevance 0.17

General Comments

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