INT300291

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.07
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
cardiomyocyte 2
heart 1
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 56 99.10 Very High Very High Very High
ketamine 4 55.12 Quite High
anesthesia 12 50.32 Quite High
Perioperative pain 4 39.44 Quite Low
Buprenorphine 4 37.12 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 312 99.12 Very High Very High Very High
Fibrosis 48 99.10 Very High Very High Very High
Apoptosis 160 98.58 Very High Very High Very High
Hypertrophy 56 98.36 Very High Very High Very High
Diabetes Mellitus 220 97.84 Very High Very High Very High
Cardiovascular Disorder Under Development 8 95.24 Very High Very High Very High
Coronary Heart Disease 40 93.40 High High
Stress 32 84.44 Quite High
Sprains And Strains 12 74.60 Quite High
Ventricular Remodeling 4 57.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study our results further showed that another Sirt1- target, FOXO3a was dephosphorylated, possibly due to Akt-kinase dephosphorylation in the diabetic GK rat heart.
Phosphorylation (dephosphorylated) of Sirt1 in heart associated with diabetes mellitus
1) Confidence 0.77 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.61 Pain Relevance 0.08
Western blotting was used to study Caspase-3, Bax, Sirt1, acetylation of p53 and phosphorylation of p38, Akt and FOXO3a.
Phosphorylation (phosphorylation) of Sirt1
2) Confidence 0.59 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.49 Pain Relevance 0.09
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Phosphorylation (phosphorylation) of Sirt1 in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
3) Confidence 0.59 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.50 Pain Relevance 0.17
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Phosphorylation (phosphorylation) of Sirt1 in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
4) Confidence 0.59 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.48 Pain Relevance 0.12

General Comments

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