INT300298

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.15
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gk) histone binding (Gk) nucleus (Gk)
carbohydrate metabolic process (Gk) cytoplasm (Gk)
Anatomy Link Frequency
myocardium 2
heart 1
Gk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 12 94.16 High High
fibrosis 56 77.88 Quite High
ischemia 4 37.60 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Perioperative pain 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 220 100.00 Very High Very High Very High
Myocardial Infarction 312 99.52 Very High Very High Very High
Hypertrophy 56 97.92 Very High Very High Very High
Apoptosis 160 96.92 Very High Very High Very High
Hypoxia 4 94.88 High High
INFLAMMATION 12 94.16 High High
Stress 32 91.12 High High
Coronary Heart Disease 40 78.96 Quite High
Fibrosis 48 77.88 Quite High
Sprains And Strains 12 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we showed an increase in the phosphorylation of the p38 MAPK in the diabetic post-infarct GK rat myocardium.
Phosphorylation (phosphorylation) of GK in myocardium associated with diabetes mellitus
1) Confidence 0.24 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.45 Pain Relevance 0.08
In the present study our results further showed that another Sirt1- target, FOXO3a was dephosphorylated, possibly due to Akt-kinase dephosphorylation in the diabetic GK rat heart.
Phosphorylation (dephosphorylation) of GK in heart associated with diabetes mellitus
2) Confidence 0.24 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.52 Pain Relevance 0.07
In the present study, we showed that decreased Akt phosphorylation in the post-infarct GK rat myocardium was associated with a decrease in the phosphorylation of FOXO3a at Akt-preferred Ser253 amino acid.
Phosphorylation (phosphorylation) of GK in myocardium
3) Confidence 0.18 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.84 Pain Relevance 0
Increased p38 MAP kinase phosphorylation in diabetic GK rats after MI
Phosphorylation (phosphorylation) of GK associated with diabetes mellitus and myocardial infarction
4) Confidence 0.18 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.34 Pain Relevance 0

General Comments

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