INT300309

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.28
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Akt1, Rorb) nucleoplasm (Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Akt1 (Rattus norvegicus)
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 28 73.12 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 20 99.32 Very High Very High Very High
Myocardial Infarction 156 98.88 Very High Very High Very High
Apoptosis 80 94.92 High High
Diabetes Mellitus 110 90.44 High High
Fibrosis 24 73.12 Quite High
Stress 16 63.32 Quite High
Obesity 2 57.80 Quite High
Hypertrophy 28 54.24 Quite High
Death 2 44.36 Quite Low
Hyperglycemia 4 35.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FOXO3a transcription factor is negatively regulated by Akt, and in the absence of Akt-mediated phosphorylation FOXO3a has been shown to induce the expression of genes implicated in the apoptotic process [20].
Akt Regulation (regulated) of transcription factor associated with apoptosis
1) Confidence 0.05 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.50 Pain Relevance 0.06
The phosphorylation status of Akt-regulated FOXO3a transcription factor was decreased in sham- and MI GK rats and MI Wistar rats (Figure 5C).
Akt Regulation (regulated) of transcription factor associated with myocardial infarction
2) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.78 Pain Relevance 0

General Comments

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