INT30031

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 11
Disease Relevance 7.46
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Hba-a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 24 96.60 Very High Very High Very High
Buprenorphine 8 92.60 High High
Morphine 12 92.00 High High
Codeine 4 89.16 High High
Opioid 20 86.12 High High
Analgesic 4 72.76 Quite High
Angina 2 65.44 Quite High
Botox 10 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thalassemia 105 99.02 Very High Very High Very High
Targeted Disruption 38 98.96 Very High Very High Very High
Pain 24 96.60 Very High Very High Very High
Diabetes Mellitus 8 95.88 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 94.20 High High
Syndrome 120 91.72 High High
Cataract 1 90.00 High High
Hypertension 2 86.88 High High
Sickle Cell Anemia 28 83.64 Quite High
Obesity 4 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of HbA1 were lower in Whites than in the other groups.
Gene_expression (Levels) of HbA1
1) Confidence 0.60 Published 1987 Journal Diabetes Care Section Abstract Doc Link 3582077 Disease Relevance 1.24 Pain Relevance 0.13
The three groups used were: 1) control C57BL mice, 2) mice with the human alpha-globin and sickle beta-globin transgenes (SC), and 3) mice with the human alpha-globin and sickle beta-globin transgenes, and homozygous for the murine alpha-globin and heterozygous for the beta(major)-gene knockout (SCKO).
Gene_expression (transgenes) of alpha-globin associated with targeted disruption
2) Confidence 0.45 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 14709626 Disease Relevance 1.06 Pain Relevance 1.05
The three groups used were: 1) control C57BL mice, 2) mice with the human alpha-globin and sickle beta-globin transgenes (SC), and 3) mice with the human alpha-globin and sickle beta-globin transgenes, and homozygous for the murine alpha-globin and heterozygous for the beta(major)-gene knockout (SCKO).
Gene_expression (homozygous) of alpha-globin associated with targeted disruption
3) Confidence 0.45 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 14709626 Disease Relevance 1.06 Pain Relevance 1.05
The three groups used were: 1) control C57BL mice, 2) mice with the human alpha-globin and sickle beta-globin transgenes (SC), and 3) mice with the human alpha-globin and sickle beta-globin transgenes, and homozygous for the murine alpha-globin and heterozygous for the beta(major)-gene knockout (SCKO).
Gene_expression (homozygous) of alpha-globin associated with targeted disruption
4) Confidence 0.45 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 14709626 Disease Relevance 1.06 Pain Relevance 1.03
The three groups used were: 1) control C57BL mice, 2) mice with the human alpha-globin and sickle beta-globin transgenes (SC), and 3) mice with the human alpha-globin and sickle beta-globin transgenes, and homozygous for the murine alpha-globin and heterozygous for the beta(major)-gene knockout (SCKO).
Gene_expression (heterozygous) of alpha-globin associated with targeted disruption
5) Confidence 0.45 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 14709626 Disease Relevance 1.08 Pain Relevance 1.06
Mean HbA1 levels during months 3-24 within the normal range (7.2 +/- 0.2%; mean +/- SEM) were observed in 20 patients (group 1), while in 12 patients (group 2) mean HbA1 of months 3-24 was elevated (10.1 +/- 0.4%).
Gene_expression (levels) of HbA1
6) Confidence 0.44 Published 1988 Journal Klin. Wochenschr. Section Abstract Doc Link 2853250 Disease Relevance 0.17 Pain Relevance 0.10
The function of the ATRX protein is unknown, but the fact that alpha globin expression is perturbed in the patients suggests that it may play a role in gene expression.
Gene_expression (expression) of alpha globin
7) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.06 Pain Relevance 0
The fact that patients with identical mutations may have very different, albeit stable, degrees of alpha thalassaemia suggests that the effect of the ATRX protein on alpha globin expression may be modified by other genetic factors.


Gene_expression (expression) of alpha globin associated with thalassemia
8) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.44 Pain Relevance 0
Thus, some patients do not have HbH inclusions [16,17,34], but this does not rule out down-regulation of alpha globin expression.
Gene_expression (expression) of alpha globin
9) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.49 Pain Relevance 0
This variable frequency of cells with HbH inclusions indicates considerable variability in the degree to which alpha globin synthesis is affected by the 736C>T mutations.
Gene_expression (synthesis) of alpha globin
10) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.43 Pain Relevance 0
To date, no change in the pattern of methylation has been detected in the alpha globin gene cluster that might explain the reduced expression of the alpha globin genes compared with expression of the beta globin genes.
Gene_expression (expression) of alpha globin
11) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.37 Pain Relevance 0

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