INT30033

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Context Info
Confidence 0.55
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.72
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (NAAA) transcription factor binding (NAAA) biological_process (NAAA)
lipid metabolic process (NAAA) lysosome (NAAA) cytoplasm (NAAA)
Anatomy Link Frequency
PLT 2
NAAA (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 92.20 High High
cINOD 16 89.76 High High
COX-2 inhibitor 5 77.16 Quite High
Pain 2 73.16 Quite High
Inflammation 27 33.60 Quite Low
licofelone 4 31.92 Quite Low
Analgesic 2 10.00 Low Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 6 95.60 Very High Very High Very High
Stroke 1 94.36 High High
Myocardial Infarction 1 93.56 High High
Pancreatitis 1 81.64 Quite High
Diabetes Mellitus 1 75.00 Quite High
Pain 2 73.16 Quite High
INFLAMMATION 39 51.36 Quite High
Disease 62 50.00 Quite Low
Cardiovascular Disorder Under Development 1 20.56 Low Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon assessment of the PLT function in the PFA-100, 27 donors showed values of greater than 180 seconds, indicative of impaired PLT function.
Negative_regulation (impaired) of PLT in PLT
1) Confidence 0.55 Published 2007 Journal Transfusion Section Body Doc Link 17207232 Disease Relevance 0 Pain Relevance 0
A relation between the reported use and impaired PLT function in blood donors could not be established, however.
Negative_regulation (impaired) of PLT in PLT
2) Confidence 0.55 Published 2007 Journal Transfusion Section Body Doc Link 17207232 Disease Relevance 0 Pain Relevance 0
RESULTS: Similar to PLT, fecal elastase concentration was significantly decreased in patients with moderate and severe CP (assessed by ERP) compared with patients with extrapancreatic disorders.
Negative_regulation (decreased) of PLT
3) Confidence 0.15 Published 1995 Journal Am. J. Gastroenterol. Section Body Doc Link 7572904 Disease Relevance 0.08 Pain Relevance 0
When the relative IC50(COX-1:COX-2) increases, the inhibition effect of the medicine on TXA2 production and PLT aggregation decreases when compared with their inhibition effect on PGI2 production (Sun and Li, 2000; Van Hecken et al, 2000).
Negative_regulation (decreases) of PLT
4) Confidence 0.10 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.49 Pain Relevance 0.51
After 24 months mean median MNCV, peroneal MNCV, median SNCV, and sural SNCV as well as both BBV tests and PLT were significantly impaired in group 2 as compared to group 1 (p less than 0.05).
Negative_regulation (impaired) of PLT
5) Confidence 0.03 Published 1988 Journal Klin. Wochenschr. Section Abstract Doc Link 2853250 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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