INT300347

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 28
Disease Relevance 25.04
Pain Relevance 9.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 35
joint 2
blood 2
thyroid 2
synovium 2
MIR146A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1564 99.88 Very High Very High Very High
cytokine 300 99.84 Very High Very High Very High
Osteoarthritis 100 99.76 Very High Very High Very High
Inflammation 347 99.64 Very High Very High Very High
psoriasis 46 94.84 High High
tolerance 23 79.76 Quite High
corticosteroid 23 56.32 Quite High
cINOD 31 47.76 Quite Low
Arthritis 23 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1564 99.88 Very High Very High Very High
Osteoarthritis 96 99.76 Very High Very High Very High
INFLAMMATION 351 99.64 Very High Very High Very High
Thyroid Neoplasm 9 99.58 Very High Very High Very High
Disease 317 99.56 Very High Very High Very High
Apoptosis 561 99.24 Very High Very High Very High
Systemic Lupus Erythematosus 46 98.96 Very High Very High Very High
Necrosis 50 97.72 Very High Very High Very High
Arthritis 54 97.68 Very High Very High Very High
Cancer 250 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synovium from RA patients exhibit increased expression of miR-146a,b, 150, and 155
Positive_regulation (increased) of Gene_expression (expression) of miR-146a in synovium associated with rheumatoid arthritis
1) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.75 Pain Relevance 0.80
In this study, we revealed that miR-146a expression was upregulated in CD4+ T cells from RA patients, exhibiting a close correlation with increased levels of TNF-?.
Positive_regulation (upregulated) of Gene_expression (expression) of miR-146a in T cells associated with rheumatoid arthritis
2) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.96 Pain Relevance 0.38
in vitro, and expression of miR-146a was found to be upregulated in a dose-dependent fashion (Figure 2b).
Positive_regulation (upregulated) of Gene_expression (expression) of miR-146a
3) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.76 Pain Relevance 0.41
Furthermore, we demonstrated that the increased expression of miR-146a suppressed T cell apoptosis by regulating Fas-associated factor 1 (FAF1).
Positive_regulation (increased) of Gene_expression (expression) of miR-146a in T cell associated with apoptosis
4) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.84 Pain Relevance 0.37
Overexpression of miR-146a suppresses T cell apoptosis but does not alter cytokine production
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miR-146a in T cell associated with apoptosis and cytokine
5) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.69 Pain Relevance 0.38
The expression level of miR-146a and IL-17 in patient RA1 and RA4 was high in comparison to the other patients. miR-146a expressed intensely with IL-17 expression in PBMC from the patients with early stage of RA and high disease activity (Figure 2B).


Positive_regulation (intensely) of Gene_expression (expressed) of miR-146a associated with rheumatoid arthritis and disease
6) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.81 Pain Relevance 0.85
The expression of miR-146a and miR-146b tended to increase with high disease activity, which was consistent with previous reports[24,25].
Positive_regulation (increase) of Gene_expression (expression) of miR-146a associated with disease
7) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.62 Pain Relevance 0.66
MiR-146a was expressed intensely with IL-17 expression in PBMC from the patients with early stage of RA and high disease activity. miR-146a/b was associated with high disease activity, and miR-150 was intensely expressed in the patients with severe joint destruction.
Positive_regulation (intensely) of Gene_expression (expressed) of MiR-146a in joint associated with rheumatoid arthritis and disease
8) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.54 Pain Relevance 0.12
The linear regression analysis showed that only miR-146a expression was positively correlated with the levels of TNF-?
Positive_regulation (only) of Gene_expression (expression) of miR-146a
9) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.66 Pain Relevance 0.33
Here, we further demonstrate that overexpression of FAF1 in miR-146a-overexpressing Jurkat T cells abolished the suppressive effect of miR-146a on T cell apoptosis.
Positive_regulation (overexpression) of Gene_expression (overexpressing) of miR-146a in T cells associated with apoptosis
10) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.82 Pain Relevance 0.04
The linear regression analysis showed that only miR-146a expression was positively correlated with the levels of TNF-?
Positive_regulation (correlated) of Gene_expression (expression) of miR-146a
11) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.66 Pain Relevance 0.34
PHA stimulation, Jurkat T cells with miR-146a overexpression showed a similar proliferative response as their controls (Figure 3b).
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-146a in T cells
12) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.43 Pain Relevance 0.23
miRNA expression profile analysis revealed that miR-146a expression was significantly upregulated while miR-363 and miR-498 were downregulated in CD4+ T cells of RA patients.
Positive_regulation (upregulated) of Gene_expression (expression) of miR-146a in T cells associated with rheumatoid arthritis
13) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911863 Disease Relevance 0.99 Pain Relevance 0.30
Moreover, increased miR-146a expression has been detected primarily in PBMC and synoviocytes from RA patients [22,25].
Positive_regulation (increased) of Gene_expression (expression) of miR-146a associated with rheumatoid arthritis
14) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.10 Pain Relevance 0.14
Although the increased expression of miR-146a in T cells does not show any affect on cytokine production in this study, available data on overexpression of miR-146a in several types of cells of RA suggests that miR-146a is possibly involved in modulating functions of T cells and other cells in RA pathogenesis.
Positive_regulation (increased) of Gene_expression (expression) of miR-146a in T cells associated with rheumatoid arthritis and cytokine
15) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.97 Pain Relevance 0.46
Compared with CD4+ T cells from peripheral blood of healthy donors, miR-146a expression was significantly increased in CD4+ T cells from both peripheral blood and SF of RA patients, while miR-498 was only down-regulated in SF T cells from patients (Figure 1c).


Positive_regulation (increased) of Gene_expression (expression) of miR-146a in T cells associated with rheumatoid arthritis
16) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.55 Pain Relevance 0.31
The role of miR-146a overexpression in regulating T cell apoptosis was evaluated by flow cytometry.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-146a in T cell associated with apoptosis
17) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911863 Disease Relevance 0.86 Pain Relevance 0.30
To further verify the effect of miR-146a overexpression on cytokine production in primary T cells, we transfected freshly prepared CD4+ T cells from peripheral blood of healthy donors and analyzed the profile of cytokine production after PMA stimulation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-146a in T cells associated with cytokine
18) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.23
Further studies are warranted to clarify whether miR-146a expression is increased in activated T cells or preferentially upregulated in memory T cells of RA patients.
Spec (whether) Positive_regulation (increased) of Spec (whether) Gene_expression (expression) of miR-146a in T cells associated with rheumatoid arthritis
19) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.67 Pain Relevance 0.34
Increased miR-146a expression in CD4+ T cell from SF and peripheral blood of RA patients
Positive_regulation (Increased) of Gene_expression (expression) of miR-146a in blood associated with rheumatoid arthritis
20) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.37 Pain Relevance 0.16

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