INT30037

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.45
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYRP1)
Anatomy Link Frequency
plasma 1
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 2 100.00 Very High Very High Very High
Opioid 4 97.60 Very High Very High Very High
Potency 4 96.72 Very High Very High Very High
Enkephalin 8 94.88 High High
opioid receptor 8 84.32 Quite High
Delta opioid receptors 2 75.00 Quite High
Pain 1 68.88 Quite High
Dopamine 24 5.00 Very Low Very Low Very Low
addiction 15 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 45 97.28 Very High Very High Very High
Infection 5 74.64 Quite High
Sprains And Strains 5 71.44 Quite High
Dyspnea 4 30.12 Quite Low
Disease 20 5.00 Very Low Very Low Very Low
Fatigue 19 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Low Back Pain 5 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A common theme that links the TRP channels is their activation or modulation by phosphatidylinositol signal transduction pathways.
TRP Binding (links) of associated with trp channel
1) Confidence 0.36 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11389472 Disease Relevance 0 Pain Relevance 0.16
For example, dose-response curves for His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (SK&F 110679) inhibition of the binding of DAGO and DPDPE yielded IC50's of 6 and 20 microM, respectively.
Trp Binding (binding) of
2) Confidence 0.35 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2853311 Disease Relevance 0 Pain Relevance 0.72
For example, dose-response curves for His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (SK&F 110679) inhibition of the binding of DAGO and DPDPE yielded IC50's of 6 and 20 microM, respectively.
Trp Binding (binding) of
3) Confidence 0.35 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2853311 Disease Relevance 0 Pain Relevance 0.72
Free-Trp was separated from protein-bound Trp by filtering plasma through 10,000 NMWL 'nominal molecular weight limit' cellulose filters (Ultrfree-MC filters, Millipore Corporation, USA) during centrifugation at 5000 g for 60 min at 4°C.
Trp Binding (bound) of in plasma
4) Confidence 0.23 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0 Pain Relevance 0
The HIV-1 protease, SPG-40, HLA-B*2705 and Con A proteins have Trp and Tyr residues on their own inhibitory peptides; and proteinase K protein binding surface contains Trp, Phe and His residues on its binding surface.
Trp Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.10 Pain Relevance 0
The HIV-1 protease, SPG-40, HLA-B*2705 and Con A proteins have Trp and Tyr residues on their own inhibitory peptides; and proteinase K protein binding surface contains Trp, Phe and His residues on its binding surface.
Trp Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.10 Pain Relevance 0
The known inhibitor Trp-Pro-Trp binding affinity for the target protein was determined by AutoDock as ?
Trp Binding (binding) of
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The tripeptide Trp-Pro-Trp sits at the active site, to which oligosaccharides bind.
Trp Binding (bind) of
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.26 Pain Relevance 0
The Viterbi program designed the tripeptide Trp-Tyr-Tyr as the sequence with possible binding affinity to SPG-40.
Trp Binding (affinity) of
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0

General Comments

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