INT300370

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 8.13
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain white matter 1
bone marrow 1
astrocytes 1
cortex 1
MIR34A (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 632 100.00 Very High Very High Very High
Central nervous system 109 97.48 Very High Very High Very High
cerebral cortex 4 97.32 Very High Very High Very High
cytokine 108 87.72 High High
Inflammation 112 87.28 High High
Glutamate receptor 4 48.72 Quite Low
Hippocampus 4 27.60 Quite Low
tolerance 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Demyelination 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 700 100.00 Very High Very High Very High
Schizophrenia 8 99.96 Very High Very High Very High
Myeloid Leukemia 3 99.84 Very High Very High Very High
Disease 314 99.56 Very High Very High Very High
Epilepsy 4 99.06 Very High Very High Very High
Repression 54 98.72 Very High Very High Very High
Neuroblastoma 18 98.08 Very High Very High Very High
Central Nervous System Disease 108 97.48 Very High Very High Very High
Apoptosis 393 95.60 Very High Very High Very High
Reprotox - General 1 60 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In another experiment, it has been revealed that miR-23b is repressed and miR-221, miR-222 and miR-34a are significantly upregulated in AML specimens compared to normal bone marrow and CD34+ haematopoietic progenitor cells [35].


Positive_regulation (upregulated) of miR-34a in bone marrow associated with myeloid leukemia
1) Confidence 0.45 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.31 Pain Relevance 0
Our qRT-PCR results showed that miR-18a, miR-193, miR-221, miR-222 and miR-7 were down-regulated, whereas miR-195, miR-30d and miR-34a were up-regulated in Par-4-transfected cells when compared with empty vector-transfected cells (Figure 8C).
Positive_regulation (up-regulated) of miR-34a
2) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.54 Pain Relevance 0
For example, the up-regulation of miR-34a and miR-195 was associated with a down-regulation of BCL2 and SGK1 protein levels, respectively; whereas the down-regulation of miR-193b, miR-221, miR-222 and miR-7 was associated with an up-regulation of MCL1, BCL2L11 (Bim), CDN1B (p 27) and VDAC1 protein levels, respectively (Figure 9A).
Positive_regulation (up-regulation) of miR-34a
3) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.36 Pain Relevance 0
Here, we hypothesized that up-regulation of miR-34a via DROSHA deregulation causes repression of BCL2 protein expression, thus contributing to the initiation of apoptotic sensitivity in Par-4-overexpressing cells.
Positive_regulation (regulation) of miR-34a associated with repression and apoptosis
4) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.76 Pain Relevance 0
Moreover, one particular deregulated microRNA miR-34a, which was up-regulated in response to overexpressed Par-4, was functionally characterized in greater detail.
Positive_regulation (up-regulated) of miR-34a
5) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.45 Pain Relevance 0
Lastly, siRNA-mediated knockdown of DROSHA in HT29 cells (thus bypassing Par-4 overexpression) was found to up-regulate miR-34a levels by more than 2-fold compared to scrambled control as defined by qRT-PCR (P < 0.05, unpaired t-test; n = 4 independent determinations).
Positive_regulation (up-regulate) of miR-34a
6) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.07 Pain Relevance 0
For instance, miR-34a up-regulation corresponded with a down-regulation of BCL2 protein.
Positive_regulation (up-regulation) of miR-34a
7) Confidence 0.10 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2883962 Disease Relevance 0.66 Pain Relevance 0
Junker et al. found that three of the most upregulated miRNAs in active MS lesions, namely, miR-155, miR-326, and miR-34a, target CD47, which was one of the downregulated transcripts in the active lesions in comparison to normal brain white matter.
Positive_regulation (upregulated) of miR-34a in brain white matter associated with multiple sclerosis
8) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.92 Pain Relevance 0.39
Although Junker et al. have focused on only three upregulated miRNAs in active MS lesions (i.e., miR-155, miR-326, and miR-34a) and their common target CD47, other upregulated miRNAs, especially miR-146a and miR-34a deserve further mention.
Positive_regulation (upregulated) of miR-34a associated with multiple sclerosis
9) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.94 Pain Relevance 0.33
MiRNA profiling in isolated cells by laser capture microdissection from active and inactive MS lesions showed that the most prominently upregulated miRNAs in active MS lesions, miR-155, miR-650, miR-34a, and miR-326 were detected in both microdissected astrocytes and infiltrating immune cells [261].
Positive_regulation (upregulated) of miR-34a in astrocytes associated with multiple sclerosis
10) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.94 Pain Relevance 0.45
They are also implicated in other CNS disorders accompanied by chronic neuroinflammatory conditions such as epilepsy, Alzheimer's disease (AD), and schizophrenia. miR-34a upregulation was determined in peripheral blood cells of sporadic AD patients, cerebral cortex of APPswe/PSDeltaE9 mice, and prefrontal cortex of schizophrenic patients [273–275].
Positive_regulation (upregulation) of miR-34a in cortex associated with epilepsy, central nervous system, disease, cerebral cortex and schizophrenia
11) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.19 Pain Relevance 0.27

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